Evidence map›Paper›PMID 40551319›Full record

ArticleJournal of the American Heart Association2025

Sex Differences in In-Hospital Mortality Among Patients Receiving Veno-Arterial Extracorporeal Membrane Oxygenation and Extracorporeal Cardiopulmonary Resuscitation: A Propensity Score-Matched Analysis.

Jung-Chi Hsu, Chen-Hsu Pai, Ling-Yi Wei, Chih-Hsien Wang, Nai-Hsin Chi, Shu-Chien Huang, Jeng-Wei Chen, Heng-Wen Chou, Ron-Bin Hsu, Nai-Kuan Chou and 3 more

Abstract readComparative Study
In one paragraph

Article in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jung-Chi HsuDepartment of Internal Medicine National Taiwan University Hospital, Jinshan Branch New Taipei City Taiwan.ORCID 0000-0002-6743-1118
Chen-Hsu PaiCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0009-0008-3141-1730
Ling-Yi WeiCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0003-1779-9915
Chih-Hsien WangCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0003-3214-6867
Nai-Hsin ChiCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0002-4731-1653
Shu-Chien HuangCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0002-0590-3474
Jeng-Wei ChenCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0001-5648-9202
Heng-Wen ChouCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0002-6263-9825
Ron-Bin HsuCardiovascular Center National Taiwan University Hospital Taipei Taiwan.
Nai-Kuan ChouCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0001-5494-7708
Hsi-Yu YuCardiovascular Center National Taiwan University Hospital Taipei Taiwan.
Lian-Yu LinDivision of Cardiology, Department of Internal Medicine National Taiwan University Hospital and College of Medicine Taipei Taiwan.ORCID 0000-0001-7505-6429
Yih-Sharng ChenCardiovascular Center National Taiwan University Hospital Taipei Taiwan.ORCID 0000-0003-3846-8162

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVeno-arterial extracorporeal membrane oxygenation (VA-ECMO) is used in cardiogenic shock, but sex-specific outcomes remain unclear. This study investigated in-hospital mortality differences by sex among patients receiving extracorporeal cardiopulmonary resuscitation (ECPR).

methodsWe retrospectively reviewed adults with cardiogenic shock treated with VA-ECMO at National Taiwan University Hospital between 2010 and 2021. After propensity score matching to improve comparability between groups, survival outcomes were assessed using Kaplan-Meier estimates, and Cox proportional hazards models were used to evaluate the effect of sex on in-hospital mortality.

resultsOf the 1329 patients (average age: 57.1±15.0 years; 953 men), 670 underwent VA-ECMO for ECPR. Women in the VA-ECMO group exhibited a lower prevalence of out-of-hospital cardiac arrest (6.7% versus 10.7%,

conclusionsWomen who underwent ECPR had higher in-hospital mortality rates regardless of the severity of their Survival After Veno-Arterial ECMO scores, despite the absence of significant sex differences in VA-ECMO mortality. This emphasizes the necessity for sex-based strategies in ECPR administration.

Indexed as

Cardiopulmonary ResuscitationExtracorporeal Membrane OxygenationHospital MortalityShock, CardiogenicAgedFemaleHumansMaleMiddle AgedPropensity ScoreRetrospective StudiesRisk FactorsSex FactorsTaiwanTreatment Outcomeextracorporeal cardiopulmonary resuscitationextracorporeal membrane oxygenationin‐hospital mortalityprognosissex difference

Identifiers

PMID40551319
PMCPMC12450006

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.