Evidence map›Paper›PMID 40551293›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.

Constance Delaby, Aurélie Ladang, Jose Martinez-Yriarte, Chiara Zecca, Giancarlo Logroscino, Peter Körtvelyessy, Hayrettin Tumani, Piero Parchi, Isabelle Quadrio, Melanie Hart and 65 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

75 authors.

Constance DelabyUniv Montpellier, LBPC-PPC, CHU Montpellier, INSERM, Montpellier, France.ORCID 0000-0002-8606-6814
Aurélie LadangClinical chemistry department, CHU de Liège, Liège, Belgium.
Jose Martinez-YriarteClinical analysis service, Hospital do Meixoeiro, Área Sanitaria de Vigo, Vigo, Spain.
Chiara ZeccaCenter for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari "A. Moro" at Pia Fondazione "Cardinale G. Panico", Tricase, Lecce, Italy.
Giancarlo LogroscinoCenter for Neurodegenerative Diseases and the Aging Brain, Department of Clinical Research in Neurology, University of Bari "A. Moro" at Pia Fondazione "Cardinale G. Panico", Tricase, Lecce, Italy.
Peter KörtvelyessyDepartment of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Hayrettin TumaniCSF Laboratory, University of Ulm, Ulm, Germany.
Piero ParchiDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.
Isabelle QuadrioBiochemistry and Molecular Biology Department, Neurodegenerative Pathologies LBMMS Hospices Civils de Lyon, BIORAN Team Lyon Neurosciences Research Center CNRS UMR 5292 INSERM U1028, Lyon, France.
Melanie HartDepartment of Neuroinflammation, UCL Queen Square Institute of Neurology, London, UK.
Dorte Aalund OlsenDepartment of Biochemistry and Immunology, University hospital of southern Denmark, Odense, Southern Denmark, Denmark.
Daniel AlcoleaDepartment of Unitat de Memoria, Hospital de la Santa Creu iSant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.
Kaj BlennowDepartment of Clinical Neurochemistry, University of Gothenburg, Mölndal, Gothenburg, Sweden.
Juan ForteaDepartment of Unitat de Memoria, Hospital de la Santa Creu iSant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.
Alberto LleoDepartment of Unitat de Memoria, Hospital de la Santa Creu iSant Pau - Biomedical Research Institute Sant Pau - Universitat Autònoma de Barcelona, Barcelona, Spain.
Alicia Algeciras-SchimnichDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Xavier AyrignacDepartment of Neurology, CHU Montpellier, INSERM, Université Montpellier, Montpellier, France.
Aurélie BedelDepartment of Biochimie, CHU de Bordeaux INSERM BRIC U1312 Université de Bordeaux, Bordeaux, France.
Gustavo A A SantosDepartment of Surgery and Anatomy, School of Medicine of Ribeirão Preto, University of Sao Paulo, Sao Paulo, Brazil.
Wyllians BorelliDepartment of Biochemistry, University of Rio Grande do Sul, Porto Alegre, Brazil.
Elodie Bouaziz-AmarDepartment of Biochemistry, Hôpital Lariboisière-Fernand Widal APHP, Université Paris Cité Paris, Paris, France.
Inês BaldeirasFaculty of Medicine of the University of Coimbra and Center for Innovative Biomedicine and Biotechnology, University of Coimbra, Coimbra, Portugal.
Edith Bigot-CorbelDepartment of Biochimie, CHU Nantes, Nantes, France.
Maria BjerkeVrije Universiteit Brussel Center for Neurosciences, Department of Clinical Biology, Clinical Neurochemistry laboratory, Universitair Ziekenhuis Brussel, Brussels, Belgium.
Mercedes Carretero PerezDepartment of Neurology, Santa Cruz de Tenerife, Tenerife, Spain.
Tiziana CasoliDepartment of Neurobiology of Ageing, IRCCS INRCA, Ancona, Italy.
Tinatin ChabrashviliDepartment of Neurology, SUNY Upstate Medical University, Syracuse, New York, USA.
Miles D ChapmanNeuroimmunology and CSF laboratory, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK.
Jessica CusatoDepartment of Medical Sciences, UNITO, Turin, Italy.
Erdinc DursunDepartment of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Anthony FourierBiochemistry and Molecular Biology Department, Neurodegenerative Pathologies LBMMS Hospices Civils de Lyon, BIORAN Team Lyon Neurosciences Research Center CNRS UMR 5292 INSERM U1028, Lyon, France.
Daniela GalimbertiDepartment of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy.
Duygu Gezen-AkDepartment of Neuroscience, Institute of Neurological Sciences, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Brian A GordonDepartment of Radiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA.
Julien GoujuMINT, INSERM U1066, CNRS 6021, CHU Angers, Angers, France.
Silvia de Las Heras FlorezDepartment of Neurology, Hospital Universitario Nuestra Señora de Candelaria Santa Cruz de Tenerife, Santa Cruz, Spain.
Juanjo Hernandez SanchezDepartment of Neurology, Unitat de Neuroquímica, Laboratori de Referència de Catalunya, Barcelona, Spain.
Marina HerwerthNeurology Department, University Hospital Zurich, Zurich, Switzerland.
Daniele ImperialeDepartment of Medical Sciences, UNITO, Turin, Italy.
Flora KaczorowskiBiochemistry and Molecular Biology Department, Neurodegenerative Pathologies LBMMS Hospices Civils de Lyon, BIORAN Team Lyon Neurosciences Research Center CNRS UMR 5292 INSERM U1028, Lyon, France.
Kensaku KasugaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Ashvini KeshavanDementia Research Centre, UCL Queen Square Institute of Neurology, London, UK.
Michael KhalilDepartment of Neurology, Medical University of Graz, Graz, Austria.
Jens KuhleDepartment of Neurology, University Hospital Basel, Basel, Switzerland.
Christoph LeithnerDepartment of Neurology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Piotr LewczukDepartment of Psychiatry and Psychotherapy, Universitätsklinikum Erlagen, Erlangen, Germany.
Franck LetournelMINT, INSERM U1066, CNRS 6021, CHU Angers, Angers, France.
Magda TsolakiDepartment of Neurology, AHEPA University Hospital, Thessaloniki, Greece.
Guido Maria GiuffrèDepartment of Neuroscience, Catholic University of the Sacred Heart, Rome, Italy.
Marie-Céline BlancBiochemistry Department, Cochin hospital, APHP, Paris, France.
Barbara MroczkoDepartment of Neurology, Medical University of Bialystok, Bialystok, Poland.
Jose Enrique Martínez RodríguezServei de Neurologia, Neuroimmunology group Hospital del Mar, IMIM, Barcelona, Spain.
Giulia MussoDepartment of Medicine, University of Padova, Padova, Italy.
Agnieszka Kulczynska-PrzybikDepartment of Neurology, Medical University of Bialystok, Bialystok, Poland.
Léonor NogueiraUMR 5165 CNRS, CHU-PURPAN, Toulouse, France.
Claire PaquetDepartment of Neurologie Cognitive, Université de Paris Cité, Paris, France.
Simone BaiardiDepartment of Biomedical and Neuromotor Sciences (DiBiNeM), University of Bologna, Bologna, Italy.
Lorenzo GaetaniDepartment of Neurology, University of Perugia, Perugia, Italy.
Lucilla ParnettiDepartment of Neurology, University of Perugia, Perugia, Italy.
Raquel Perez GarayDepartment of Clinical Analysis Service, Cruces University Hospital-OSAKIDETZA, Immunopathology Research Group, Biobizkaia Health Research Institute, Barakaldo, Spain.
Koen PoesenAlzheimer Research Centre, Leuven Brain Institute, KU Leuven, Leuven, Belgium.
Muriel Quillard-MuraineClinical Biology Center, Rouen University Hospital, Rouen, France.
Enrique Rodriguez BorjaHospital Clinico Universitario de Valencia Laboratorio de Bioquimica Clínica y Patología Molecular, Valencia, Spain.
Susanna SchraenDepartment of Biochemistry, CHU de Lille, Lille, France.
Daniela TerraccianoDepartment of Translational Medical Sciences, University Federico II, Naples, Italy.
Franziska BachhuberDepartment of Translational Medical Sciences, University Federico II, Naples, Italy.
Steffen HalbgebauerCSF Laboratory, University of Ulm, Ulm, Germany.
Socrates TzartosTzartos NeuroDiagnostics, Athens, Greece.
John TzartosDepartment of Neurology, Second Department of Neurology, National & Kapodistrian University of Athens, Athens, Greece.
Nadine UnterwalderDepartment of Neurology, LaborBerlin, Berlin, Germany.
Lisa VermuntNeurochemistry Laboratory, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Cheryl L WellingtonDepartment of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.
Henrik ZetterbergDepartment of Clinical Neurochemistry, University of Gothenburg, Mölndal, Gothenburg, Sweden.
Charlotte TeunissenNeurochemistry Laboratory, Alzheimer Center Amsterdam, Amsterdam Neuroscience, Neurodegeneration, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Sylvain LehmannUniv Montpellier, LBPC-PPC, CHU Montpellier, INSERM, Montpellier, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNeurofilament light chain (NfL) quantification aids in diagnosing and predicting neurological disorders, but clinical and laboratory practices vary across centers. Differences in result interpretation and reporting further challenge test commutability. This study aimed to review the global analytical and post-analytical methods used for NfL measurement in routine clinical practice across different contexts.

methodsWe established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.

resultsAmong the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%). DISCUSSION: Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice. HIGHLIGHTS: Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.

Indexed as

Nervous System DiseasesNeurofilament ProteinsBiomarkersHumansPractice Guidelines as TopicSurveys and QuestionnairesBiomarkersneurofilament protein LNeurofilament Proteinsbiomarkersbloodcerebrospinal fluidclinical reportconsensus approachharmonizationneurofilaments

Identifiers

PMID40551293
PMCPMC12185249

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.