ArticleNutrition & metabolism2025
Association of behavioral factors, liver function and NAFLD: Bayesian Mendelian randomization.
Article in Nutrition & metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Association of geriatric nutritional risk index with metabolic dysfunction-associated steatotic liver disease and subtypes in Chinese elderly: identification of an overnutrition risk threshold and implications for extended risk stratification.Frontiers in nutrition · 2026Article
- CXCL10 promotes non-small cell lung cancer (NSCLC) progression by modulating the phosphate to urate ratio (PUR).Discover oncology · 2025Article
- SII and lung cancer in middle-aged and elderly population: the nonlinear connection and the mediating role of ABSI.World journal of surgical oncology · 2025Article
- Nano-Enhanced Diets: Advancing Metabolic Dysfunction-Related Steatotic Liver Disease (MASLD) - A Review.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Review
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3 authors.
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Abstract
backgroundThe causal associations between behavioral factors (BFs) and the risk of non-alcoholic fatty liver disease (NAFLD), and whether liver function mediates these associations, remain unclear. Therefore, this study aimed to assess these associations.
methodsWe performed two-sample Mendelian randomization (2SMR) and multivariable MR (MVMR) analysis using summary-level data to assess the associations between BFs and NAFLD. The linkage disequilibrium score regression (LDSC) was used for genetic correlation analysis. Additionally, we utilized NHANES database to assess dose-response relationships. Furthermore, we applied two-sample MVMR approach based on Bayesian model averaging (MR-BMA) to identify the most influential liver function index as a mediating factor, and performed mediation analysis.
results2SMR results showed that leisure screen time (ST, β = 0.414, P = 5.91e-6) and smoking initiation (SI, β = 0.164, P = 0.012) were associated with NAFLD risk with no reverse causality. LDSC supported these associations (SI: rg = 0.291, P = 1.04e-8; ST: 0.518, P = 5.41e-21). However, MVMR showed that only ST was independently associated with NAFLD (β = 0.334, P = 4.6e-5). There was a linear relationship between ST and NAFLD, and NAFLD risk increased significantly after 5 h of ST. Alanine transaminase level was the most influential index (ALT, MIP = 0.452) and mediated 54% of the ST-NAFLD association.
conclusionST is independently associated with an increased risk of NAFLD. It is recommended to avoid more than 5 h of ST per day. ALT is the most influential liver function index associated with NAFLD and mediates the ST-NAFLD association.
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