Evidence map›Paper›PMID 40551129›Full record

ArticleJournal of neuroinflammation2025

Group 2 innate lymphoid cells drive inhibitory synapse formation with lasting effects on learning and memory.

Johannes Steffen, Divija Deshpande, Henning Peter Düsedau, Janna Schmitz, Caio Andreeta Figueiredo, Laura Velleman, Claudia Pitzer, Christoph S N Klose, Ildiko R Dunay

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroinflammation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Johannes Steffen *Institute of Inflammation and Neurodegeneration, Otto-Von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-0647-4157
Divija Deshpande *Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-9166-2509
Henning Peter DüsedauInstitute of Inflammation and Neurodegeneration, Otto-Von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.ORCID http://orcid.org/0000-0002-0805-4084
Janna SchmitzDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
Caio Andreeta FigueiredoInstitute of Inflammation and Neurodegeneration, Otto-Von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany.ORCID http://orcid.org/0000-0003-1517-5957
Laura VellemanDepartment of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.
Claudia PitzerInterdisciplinary Neurobehavioral Core, Ruprecht-Karls-Universität Heidelberg, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7663-1031
Christoph S N Klose *Department of Microbiology, Infectious Diseases and Immunology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität Zu Berlin, Berlin, Germany.ORCID http://orcid.org/0000-0001-8803-2979
Ildiko R Dunay *Institute of Inflammation and Neurodegeneration, Otto-Von-Guericke University, Leipziger Straße 44, 39120, Magdeburg, Germany. ildiko.dunay@med.ovgu.de.ORCID http://orcid.org/0000-0002-9900-8605

Funding

Deutsche Forschungsgemeinschaft DFG KL 2963/2-1Deutsche Forschungsgemeinschaft DU1112/5-1
6 · The paper itself

Abstract

The immune system provides multiple layers of protection that extend beyond conventional pathogen defense, including context-dependent modulation of behavior. However, the mechanisms driving these immune-mediated behavioral modifications remain incompletely understood. Here, we demonstrate that group 2 innate lymphoid cells (ILC2s) shape hippocampal synaptic development during early postnatal stages, with lasting effects on adult behavior, learning, and memory.Using flow synaptometry, we identified a selective reduction in hippocampal VGAT

Indexed as

HippocampusImmunity, InnateLearningLymphocytesMemoryNeural InhibitionSynapsesAnimalsAnimals, NewbornMaleMiceMice, Inbred C57BLMice, Knockout

Identifiers

PMID40551129
PMCPMC12183876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.