ArticleWorld journal of surgical oncology2025
Survival outcomes after surgical resection of huge HCC (≥ 10 cm) with or without neoadjuvant hepatic arterial infusion chemotherapy.
Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the survival outcomes of huge HCC (tumor size ≥ 10 cm) after surgical resection (SR) with or without neoadjuvant hepatic arterial infusion chemotherapy (HAIC). PATIENTS AND
methods119 huge HCC patients underwent SR in our Hospital (2010-2020). A new HAIC regimen (cisplatin, leucovorin, mitomycin-C and 5-FU infusion for 5 days plus 10 ml lipiodol microvascular embolization) was adopted as the neoadjuvant therapy in 25 patients. Treatment responses were evaluated based on mRECIST criteria. The objective response rate (ORR), disease free survival (DFS), recurrence survival (RS) and overall survival (OS) were compared between the SR-only and neoadjuvant HAIC groups.
resultsOf the 119 patients, 65 patients were Vp2, 9 patients were Vp3 and 4 patients were Vp4. In the subgroup analysis, neoadjuvant HAIC group revealed significantly more severe clinical status. Of the neoadjuvant HAIC patients, ORR was 66.7%. Postoperative tumor recurrence was noted in 75% and 58.3% of the SR and neoadjuvant groups, of them 56.5% and 20.8% developed in ≤ 12 months. The median DFS, RS and OS in each group were 10 vs. 41 months (p = 0.016), 36 vs. 91 months and 46 vs. 96 months, respectively. Subgroup analysis revealed no significant survival difference of the RS in both patient groups with tumor recurrence ≤ 12 months (17 vs. 14 months) or > 12 months/without recurrence (not reached vs. 113 months).
conclusionOur new regimen HAIC acted as an effective neoadjuvant therapy in reducing early recurrence rate and prolonged DFS of huge HCC after surgical resection.
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