ArticleInternational journal of emergency medicine2025
Sepsis in patients with severe TBI: a retrospective CT scoring study.
Article in International journal of emergency medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMultiple organ failure (MOF) is a severe complication associated with high mortality in sepsis after severe TBI (sTBI).
objectiveTo investigate the usefulness of a rapid computed tomography (CT) screening score for predicting of mortality and outcomes of sepsis after sTBI.
methodsWe retrospectively analyzed those data of patients who were admitted to the ICU. All sTBI patients with or without sepsis underwent rapid CT screening before ICU admission and were admitted to the ICU for > 24 h were included in this study. The main outcome was sepsis-related the mortality after sTBI. The secondary outcome was the GOSE score during the first 60 days.
resultsAmong a random sample of 412 adult patients with sTBI, we found 249 sepsis after sTBI (60.4%) and 163 (39.6%) non- sepsis after sTBI events. The main organ failure was early brain (94.8%) and lung injury(91.2%) caused by community-acquired pnumonia (CPA). The CT score was higher in the sTBI with sepsis group than in the sTBI without sepsis group(wean 3.5 score vs. 0.9 score, p < 0.001).The SOFA score was also higher in the sTBI with sepsis group than in the sTBI without sepsis group(wean 5.9 score vs. 3.6 score, p < 0.001). The risk of death for sepsis after sTBI was an elevated CT score (hazard ratio[HR], 4.6; 95% confidence interval[CI], 3.373-10.49; p < 0.001) and an elevated SOFA score (HR,3.0; 95% CI, 2.054-4.826; p < 0.001).The area under the ROC curve for mortality was significantly larger for the elevated CT score (0.90, 95%CI 0.86-0.97 ) than for the elevated score (0.85, 95%CI 0.81-0.89 ) (P < 0.001). The elevated CT score in the area under the ROC curve for mortality was with 97.0% of sensitivity and 100.0% of specificity. At 60 days follow-up, the risk of death for sepsis after sTBI was higher than those non- sepsis after sTBI (p < 0.001).
conclusionsElevated CT score is a well indicator of high incidence and mortality for sepsis after sTBI in the ICU, which suggests that this very current and practical event is involved to a global health care problem. But it could still need further verification in future investigation.
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