Evidence map›Paper›PMID 40551069›Full record

Trial reportAIDS and behavior2025

Randomized Controlled Trial of a Couples-Based HIV Intervention for Transgender Women and Their Partners: Findings from the "It Takes Two" Project.

Kristi E Gamarel, Don Operario, Ellen S Stein, Lance M Pollack, Torsten B Neilands, Breonna McCree, Jack Johnson, Wesley M Correll-King, David Olem, Mallory O Johnson and 1 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in AIDS and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kristi E GamarelDepartment of Health Behavior and Health Equity, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA. kgamarel@umich.edu.ORCID http://orcid.org/0000-0001-9405-7515
Don OperarioDepartment of Behavioral, Social, and Health Education Sciences, Emory University Rollins School of Public Health, Atlanta, GA, USA.
Ellen S SteinDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Lance M PollackDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Torsten B NeilandsDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Breonna McCreeDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jack JohnsonDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Wesley M Correll-KingPopulation Studies Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
David OlemDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Mallory O JohnsonDepartment of Medicine, University of California, San Francisco, San Francisco, CA, USA.
Jae M SeveliusDepartment of Psychiatry, Columbia University, New York, NY, USA.

Funding

TRAINING IN THE DEMOGRAPHY OF AGINGT32AG000221 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sarah A. Burgard · 1992 to 2026
$15.3M
Scientific/Technical CoreP2CHD041028 · NICHD · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Sarah A. Burgard · 2017 to 2026
$6.5M
Training Program for Scientists Conducting Research to Reduce HIV Health DisparitR25MH067127 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Emily A Arnold, Torsten Brian Neilands · 2003 to 2026
$5.4M
A couples-based approach to HIV prevention for transgender women and their male partnersR01MH115765 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI GAMAREL, KRISTI E, OPERARIO, DON · 2018 to 2022
$2.9M
The Johns Hopkins and Emory University AIDS Research Center – Center for HIV and Mental Health Stigma Elimination Strategies (CHIMES) P30MH136919 · NIMH · JOHNS HOPKINS UNIVERSITY · PI Stefan David Baral, Patrick Sean Sullivan · 2024 to 2026
$2.9M
NIA NIH HHS T32 AG000221NICHD NIH HHS P2C HD041028NIMH NIH HHS P30 MH136919NIMH NIH HHS R01 MH115765NIMH NIH HHS R01MH115765NIMH NIH HHS R25 MH067127
6 · The paper itself

Abstract

"It Takes Two" is a couples-based HIV prevention program designed for transgender women and their partners. The aim of this project is to alleviate HIV vulnerability by enhancing communication, improving shared goals, and decreasing relationship stigma. From November 2019 to November 2022, we conducted a randomized controlled trial with 52 couples (104 individuals). Participants were randomized into one of two groups: the intervention group received four 1-hour counseling sessions, while the control group received educational videos. Due to the COVID-19 pandemic, 60% of participants took part in a fully digital trial, including telehealth counseling. Assessments were conducted at baseline and at 3, 6, 9, and 12 months. We analyzed the outcomes using multilevel random coefficient models. While the intervention did not significantly impact HIV vulnerability, communication, or shared goals, there were reductions in relationship stigma among partners of transgender women at 3- (Cohen's d = 0.54), 6- (Cohen's d = 0.57), and 12-months (Cohen's d = 0.72) post-intervention. These findings highlight the importance of addressing relationship stigma and involving partners in HIV prevention efforts to promote the health of transgender women.

Indexed as

CounselingHIV InfectionsSexual PartnersTransgender PersonsAdultCOVID-19FemaleHumansMaleMiddle AgedSARS-CoV-2Social StigmaTelemedicineCouples-based HIV Prevention InterventionTransgender Women

Identifiers

PMID40551069
PMCPMC12266223

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.