Evidence map›Paper›PMID 40551050›Full record

ArticleMolecular neurobiology2025

Xuebijing Promotes HMGB1-Mediated Autophagy to Alleviate Oxidative Stress and Inflammation in Heat Stroke-Induced Brain Damage.

Hongbo Li, Chunhe Li, Jun Li, Yongrui Liu, Minyong Wen, Lin Wang

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hongbo LiDepartment of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China.
Chunhe LiDepartment of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China.
Jun LiEmergency Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China.
Yongrui LiuEmergency Department, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China.
Minyong WenDepartment of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China. WMY_ICU@126.com.
Lin WangDepartment of Intensive Care Unit, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, Guangdong, 510405, People's Republic of China. Wlin_yfy@163.com.

Funding

Guangzhou Science and Technology Project 202102080465National Natural Science Foundation, China Youth Science Foundation Project 82104572
6 · The paper itself

Abstract

Heat stroke (HS) is a life-threatening condition with complex underlying mechanisms, posing challenges for pharmacological treatment. Xuebijing (XBJ) can effectively relieve HS-induced brain injury, but its molecular mechanism is not well-established. This study was conducted to investigate the mechanisms underlying the protective role of XBJ in HS-induced brain injury. HS-induced mice and cell models were established to elucidate the protective effects and underlying mechanisms of XBJ on HS-induced brain injury in vivo and in vitro. HMGB1 knockout (HMGB1

Indexed as

AutophagyBrain InjuriesDrugs, Chinese HerbalHeat StrokeHMGB1 ProteinInflammationOxidative StressAnimalsApoptosisMaleMiceMice, Inbred C57BLMice, KnockoutNeuronsReactive Oxygen SpeciesDrugs, Chinese HerbalHMGB1 ProteinReactive Oxygen SpeciesAutophagyBrain injuryHeat strokeInflammationOxidative stressXuebijing

Identifiers

PMID40551050

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.