Evidence map›Paper›PMID 40551025›Full record

ArticleNature neuroscience2025

Large-scale high-density brain-wide neural recording in nonhuman primates.

Eric M Trautmann, Janis K Hesse, Gabriel M Stine, Ruobing Xia, Shude Zhu, Daniel J O'Shea, Bill Karsh, Jennifer Colonell, Frank F Lanfranchi, Saurabh Vyas and 18 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. A Framework for Compressive On-Chip Action Potential Recording.IEEE transactions on bio-medical engineering · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Review
  19. Review
  20. Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

28 authors.

Eric M TrautmannDepartment of Neuroscience, Columbia University Medical Center, New York, NY, USA. etrautmann@gmail.com.ORCID http://orcid.org/0000-0001-5552-2023
Janis K Hesse *Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA.
Gabriel M Stine *McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ruobing Xia *Department of Neurobiology, Stanford University, Stanford, CA, USA.
Shude Zhu *Department of Neurobiology, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-8674-9607
Daniel J O'SheaDepartment of Electrical Engineering, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0002-1366-1743
Bill KarshJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0009-0009-5977-7731
Jennifer ColonellJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0009-0009-3940-0689
Frank F LanfranchiComputation & Neural Systems, California Institute of Technology, Pasadena, CA, USA.
Saurabh VyasZuckerman Institute, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-5406-3272
Andrew ZimnikDepartment of Neuroscience, Columbia University Medical Center, New York, NY, USA.
Elom AmematsroDepartment of Neuroscience, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0003-4843-4513
Natalie A SteinemannDepartment of Neuroscience, Columbia University Medical Center, New York, NY, USA.
Daniel A WagenaarDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0002-6222-761X
Marius PachitariuJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0001-7106-814X
Alexandru AndreiIMEC, Leuven, Belgium.
Carolina Mora LopezIMEC, Leuven, Belgium.ORCID http://orcid.org/0000-0003-4200-0001
John O'CallaghanIMEC, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2313-8697
Jan PutzeysIMEC, Leuven, Belgium.ORCID http://orcid.org/0000-0001-8834-5852
Bogdan C RaducanuIMEC, Leuven, Belgium.ORCID http://orcid.org/0000-0003-2207-6260
Marleen WelkenhuysenIMEC, Leuven, Belgium.ORCID http://orcid.org/0000-0001-6729-9391
Mark ChurchlandDepartment of Neuroscience, Columbia University Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9123-6526
Tirin MooreDepartment of Neurobiology, Stanford University, Stanford, CA, USA. tirin@stanford.edu.ORCID http://orcid.org/0000-0002-3345-2930
Michael ShadlenDepartment of Neuroscience, Columbia University Medical Center, New York, NY, USA.
Krishna ShenoyHoward Hughes Medical Institute, Stanford University, Stanford, CA, USA.
Doris TsaoDepartment of Molecular and Cell Biology, University of California, Berkeley, CA, USA.ORCID http://orcid.org/0000-0003-1083-1919
Barundeb DuttaIMEC, Leuven, Belgium. barundeb.dutta@imec.be.ORCID http://orcid.org/0000-0003-4781-9630
Timothy HarrisJanelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA, USA.ORCID http://orcid.org/0000-0002-6289-4439

Funding

Interaction of Visual and Oculomotor Signals in CortexR01EY014924 · NEI · STANFORD UNIVERSITY · PI MOORE, TIRIN · 2004 to 2024
$7.3M
Vision Sciences Training GrantT32EY013933 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Carol A. Mason, CAROL M TROY · 2001 to 2026
$5.3M
Understanding the circuit for topological object trackingDP1NS083063 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI TSAO, DORIS YING · 2012 to 2016
$4.1M
DISCOVERING THE RULES FOR THE ORGANIZATION OF MACAQUE INFEROTEMPORAL CORTEX.R01EY030650 · NEI · UNIVERSITY OF CALIFORNIA BERKELEY · PI TSAO, DORIS YING · 2019 to 2022
$2.3M
Computational and circuit mechanisms of decision makingR01NS113113 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHADLEN, MICHAEL NEIL · 2019 to 2023
$2.2M
Determining the Sources of Motor-Cortex Response ComplexityR01NS135240 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Mark M Churchland · 2024 to 2026
$1.9M
Uncovering the neural architecture underlying decisions abstracted from movementsR01MH122513 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BICKEL, STEPHAN, KELLY, SIMON · 2020 to 2024
$1.9M
Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and AttentionRF1NS116623 · NINDS · STANFORD UNIVERSITY · PI MOORE, TIRIN, SHENOY, KRISHNA V · 2020 to 2022
$1.8M
Large-scale recordings in Primate Prefrontal Cortex: Mechanisms of Value and AttentionR01NS116623 · NINDS · STANFORD UNIVERSITY · PI MOORE, TIRIN, WALLIS, JONI D · 2023 to 2024
$1.0M
Interaction of Visual and Oculomotor Signals in CortexR56EY014924 · NEI · STANFORD UNIVERSITY · PI MOORE, TIRIN · 2009 to 2009
$398k
Parieto-collicular interactions during perceptual decisionsF31EY032791 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STINE, GABRIEL M · 2021 to 2021
$36k
Brain and Behavior Research Foundation (Brain & Behavior Research Foundation) NARSAD 29752NEI NIH HHS F31 EY032791NEI NIH HHS R01 EY014924NEI NIH HHS R01 EY030650NEI NIH HHS R56 EY014924NEI NIH HHS T32 EY013933NIMH NIH HHS R01 MH122513NINDS NIH HHS DP1 NS083063NINDS NIH HHS R01 NS113113NINDS NIH HHS R01 NS116623NINDS NIH HHS R01 NS135240NINDS NIH HHS RF1 NS116623
6 · The paper itself

Abstract

High-density silicon probes have transformed neuroscience by enabling large-scale neural recordings at single-cell resolution. However, existing technologies have provided limited functionality in nonhuman primates (NHPs) such as macaques. In the present report, we describe the design, fabrication and performance of Neuropixels 1.0 NHP, a high-channel electrode array designed to enable large-scale acute recording throughout large animal brains. The probe features 4,416 recording sites distributed along a 45-mm shank. Experimenters can programmably select 384 recording channels, enabling simultaneous multi-area recording from thousands of neurons with single or multiple probes. This technology substantially increases scalability and recording access relative to existing technologies and enables new classes of experiments that involve electrophysiological mapping of brain areas at single-neuron and single-spike resolution, measurement of spike-spike correlations between cells and simultaneous brain-wide recordings at scale.

Indexed as

Action PotentialsBrainBrain MappingElectrodes, ImplantedNeuronsAnimalsMacaca mulatta

Identifiers

PMID40551025
PMCPMC12229894

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.