ArticleNature neuroscience2025
Closed-loop electrical stimulation prevents focal epilepsy progression and long-term memory impairment.
Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed.
- Tissue-bioelectronics interfaces.Chemical Society reviews · 2026Review
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Theta Oscillations, Oculomotor Processing, and Neural Synchronization: A Review.Brain sciences · 2026Review
- Neuronal silence as a predictive biomarker and target for epileptic seizures suppression.Scientific reports · 2026Article
- Passive neuromodulation: an energy-driven mechanism for closed-loop suppression of epileptic seizures.bioRxiv : the preprint server for biology · 2026Article
- Post-Ictal Sleep Changes in Human Focal Epilepsy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Materials and System Design for Self-Decision Bioelectronic Systems.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Gastrodin alleviates neuronal damage in epileptic cell models by targeting P2RY12 to inhibit microglial hyperactivation.PloS one · 2026Article
- High-frequency, low-energy organic event-based sensors for closed-loop neurostimulation.Nature sensors · 2026Article
- Bridging the translational gap in systems neuroscience: from circuit mechanisms to clinical therapeutics.Frontiers in pharmacology · 2026Review
- Designing Neural Dynamics: From Digital Twin Modeling to Regeneration.International journal of molecular sciences · 2025Review
- Interneuron theta phase locking controls seizure susceptibility.bioRxiv : the preprint server for biology · 2025Article
- The role of electroencephalography in epilepsy research-From seizures to interictal activity and comorbidities.Epilepsia · 2025Review
Corrections and comments
- Update of
Authors and funding
13 authors.
Funding
Abstract
Interictal epileptiform discharges (IEDs) are expressed in epileptic networks and disrupt cognitive functions. It is unclear whether addressing IED-induced dysfunction could improve epilepsy outcomes, as most therapeutic approaches target seizures. We show, in a kindling model of progressive focal epilepsy, that IEDs produce pathological oscillatory coupling associated with prolonged, hypersynchronous neural spiking in synaptically connected cortex and expand the brain territory capable of generating IEDs. A similar relationship between IED-mediated oscillatory coupling and temporal organization of IEDs across brain regions was identified in human participants with refractory focal epilepsy. Spatiotemporally targeted closed-loop electrical stimulation triggered on hippocampal IED occurrence eliminated the abnormal cortical activity patterns, preventing the spread of the epileptic network and ameliorating long-term spatial memory deficits in rodents. These findings suggest that stimulation-based network interventions that normalize interictal dynamics may be an effective treatment of epilepsy and its comorbidities, with a low barrier to clinical translation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.