Hybrid g-C₃N₄/ZnO nanocomposites for enhanced electrochemical detection of dengue virus serotype 2 (DENV2) NS1 protein biomarker.

Manikandan M, Dhanalakshmi C, Lakshmi Priya G, Manikandan E, Kiran Kumar Tadi

Abstract read

In one paragraph

Article in Mikrochimica acta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Manikandan MSchool of Electronics Engineering, Vellore Institute of Technology, Chennai, 600127, India.

Dhanalakshmi CSchool of Advanced Sciences, Vellore Institute of Technology, Chennai, 600127, India.

Lakshmi Priya GCentre for Advanced Materials and Innovative Technologies, Vellore Institute of Technology, Chennai, 600127, India. lakshmipriya.g@vit.ac.in.

Manikandan ECentre for Advanced Materials and Innovative Technologies, Vellore Institute of Technology, Chennai, 600127, India.

Kiran Kumar TadiSchool of Advanced Sciences, Vellore Institute of Technology, Chennai, 600127, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early detection of dengue virus (DENV) is crucial for effective disease control and reducing severe complications. Among its four serotypes, DENV2 is strongly associated with severe outcomes, emphasizing the need for timely diagnosis. This study presents a highly sensitive and selective electrochemical biosensor based on hybrid graphitic carbon nitride (g-C₃N₄)/ZnO nanocomposites for detecting DENV2 non-structural protein 1 (NS1), a key biomarker for early dengue diagnosis. The structural and morphological features of the nanocomposites were characterized using XRD, FTIR, UV-Vis, SEM, TEM, AFM, and XPS. The sensor was constructed by modifying a glassy carbon electrode (GCE) with the synthesized g-C₃N₄/ ZnO nanocomposite, further functionalized with 1-pyrenebutyric acid N-hydroxy succinimide ester (Pyr-NHS) for immobilizing the DENV2 NS1 antibody. The g-C

Indexed as

Biosensing TechniquesDengue VirusElectrochemical TechniquesGraphiteNanocompositesNitrogen CompoundsViral Nonstructural ProteinsZinc OxideAntibodies, ImmobilizedBiomarkersDengueElectrodesHumansLimit of DetectionAntibodies, ImmobilizedBiomarkersGraphitegraphitic carbon nitrideNitrogen CompoundsNS1 protein, Dengue virus type 2Viral Nonstructural ProteinsZinc OxideAntibodyDPVG-C₃N₄/ZnO nanocompositesModified glassy carbon electrodeNS1-antigen

Identifiers

PMID40551020

DOI10.1007/s00604-025-07307-6

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.