SynthesisScience China. Life sciences2025
Global burden and characterization of hypertriglyceridemia-induced acute pancreatitis: results from a systematic review and a multi-center cohort study.
Synthesis in Science China. Life sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of GLP-1 Agonists on Prevention of HTG-Induced Acute Pancreatitis Recurrence: Protocol for a Randomized Clinical Trial
Effect of Bacillus Subtilis and Enterococcus Faecium Combination Therapy Combined With Conventional Lipid-Lowering Treatment on Triglyceride Levels in Patients With Hypertriglyceridemic Acute Pancreatitis: A Prospective Randomized Controlled Trial
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Evaluating the efficacy of intensified insulin therapy in hypertriglyceridemic acute pancreatitis management: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Review
- Article
- Tricellulin regulates the tight junctions and cytoskeleton of pancreatic acinar cells through the NF-κB pathway in hypertriglyceridemic acute pancreatitis.Biomedical reports · 2026Article
- Triglyceride Threshold for Intensive Lipid-Lowering Therapy in Acute Hyper-Triglyceridemic Pancreatitis: A Retrospective Study.Journal of clinical medicine · 2026Article
- Phenyllactic Acid Restores Intestinal Epithelial Barrier to Alleviate Hypertriglyceridemic Acute Pancreatitis via a PPARγ-Dependent Mechanism.Antioxidants (Basel, Switzerland) · 2026Article
- Comparison of the efficacy and safety of nafamostat mesylate and heparin in blood purification therapy for patients with severe acute pancreatitis: protocol for a randomized controlled trial.Frontiers in medicine · 2026Article
- An explainable machine learning framework integrating clinical and lipidomic signatures for early severity stratification of hypertriglyceridemic pancreatitis.Frontiers in medicine · 2026Article
- Combining MRI dual-sequence radiomics and clinical parameters predicts post-hypertriglyceridemic acute pancreatitis diabetes mellitus.Frontiers in endocrinology · 2026Article
- Nomogram for Predicting Pancreatic Pseudocyst in Hypertriglyceridemic Acute Pancreatitis: A Retrospective Cohort Study.Journal of inflammation research · 2026Article
- Development and Validation of an Early Severity Prediction Model for Hypertriglyceridemia-Associated Acute Pancreatitis: A Multicenter Cohort Study.Journal of inflammation research · 2026Article
- Association between peak D-dimer levels within 24 hours of admission and the risk of infected pancreatic necrosis in hyperlipidemic acute pancreatitis: a retrospective analysis.Frontiers in medicine · 2026Article
- Gut microbiota-host co-metabolism in hypertriglyceridemia-associated acute pancreatitis: from causality to precision intervention.Frontiers in immunology · 2026Review
- An Interpretable Machine Learning Model for Predicting in-Hospital Progression in Initially Mild Hypertriglyceridemia-Induced Acute Pancreatitis Using Clinical and Non-Contrast CT Features.International journal of general medicine · 2026Article
- Hypertriglyceridemic pancreatitis: perspectives from China.Current opinion in gastroenterology · 2025Review
- Ferroptosis in Hypertriglyceridemic Acute Pancreatitis: Mechanisms and Therapeutic Implications.Journal of inflammation research · 2025Review
- Developing a Health Literacy Intervention for Hypertriglyceridemia-Induced Acute Pancreatitis: A Timing It Right Framework.Patient preference and adherence · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To compare and characterize hypertriglyceridemia-induced acute pancreatitis (HTG-AP) across the geographical regions, we conducted a systematic review and a multi-center cohort study. We conducted a systematic review and random effects meta-analysis of studies reporting HTG-AP. Also, we separately characterized HTG-AP in a multi-center retrospective cohort study involving eight centers in China. The key outcomes of interest included the pooled proportion of HTG-AP and its severity parameters after adjusting for the effect of confounding factors through logistic regression. Our systematic review identified 110 studies from 15 countries accounting for 3,057,428 participants (35% female, median age 50 years). The pooled proportion of HTG-AP was 11.6% globally while the Eastern and Western countries reported the proportions as 16.3% and 5.4%, respectively (P<0.01). The pooled mortality rate was remarkably higher in Eastern countries (4.1%) than in Western countries (1.0%) (P<0.01). 3,224 participants (37% female, median age 48 years) were included in our multi-center cohort study, and the proportion of HTG-AP was much higher at 35.9% with a nearly three-fold higher mortality rate compared with acute pancreatitis (AP) due to other etiologies (odds ratio (OR): 2.77, 95% confidence interval (CI): 1.60 to 4.81). The proportion of patients with HTG-AP is remarkably higher in Eastern countries, particularly China, than in Western countries. Furthermore, compared with other causes of AP, HTG-AP has a poorer prognosis and may warrant aggressive management.
Indexed as
Identifiers
40550999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.