Evidence map›Paper›PMID 40550992›Full record

ArticleArchives of toxicology2025

Crotalus durissus terrificus snake venom activates 3T3-L1 preadipocytes to release PGE

Danilo Santos Teixeira, Rodrigo Maia-Marques, Catarina Teixeira

Abstract read
In one paragraph

Article in Archives of toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Danilo Santos Teixeira *Laboratory of Pharmacology, Instituto Butantan, Sao Paulo, Brazil.ORCID 0000-0002-7601-5191
Rodrigo Maia-Marques *Laboratory of Pharmacology, Instituto Butantan, Sao Paulo, Brazil. rodrigomaiamarques@gmail.com.ORCID 0000-0003-0630-8316
Catarina TeixeiraLaboratory of Pharmacology, Instituto Butantan, Sao Paulo, Brazil. catarina.teixeira@butantan.gov.br.ORCID 0000-0001-5887-7663

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 310930/2019-7Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.569469/2020-00Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.655304/2021-00
6 · The paper itself

Abstract

Snakebites are a worldwide public health problem with high-cost treatment in many countries. Crotalus genus snakes, commonly known as rattlesnakes, cause the most lethal snakebites in Brazil. Crotalus ssp envenomation is characterised by systemic neurotoxicity, myotoxicity, renal failure and minor local effects. Despite the knowledge of envenomation's pathogenesis, the impact of Crotalus venom on adipose tissue (AT) cells is unknown. AT is an endocrine organ capable of releasing diverse immunomodulatory molecules, including prostaglandin E

Indexed as

CrotalusCyclooxygenase 2DinoprostoneSnake Venoms3T3-L1 CellsAdipocytesAdipose TissueAnimalsHumansMiceReceptors, Prostaglandin E, EP2 SubtypeSnake BitesVenomous SnakesCyclooxygenase 2DinoprostoneReceptors, Prostaglandin E, EP2 SubtypeSnake VenomsCrotalus durissus snake venomPGE2 receptorsPreadipocyteProstaglandin E2

Identifiers

PMID40550992
PMCPMC12454571

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.