Evidence map›Paper›PMID 40550985›Full record

ArticleReproductive sciences (Thousand Oaks, Calif.)2025

Beneficial Effects of Alchemilla vulgaris in DHEA-Induced Rat Model of Polycystic Ovary Syndrome.

Zeynep Ece Utkan Korun, Semil Selcen Gocmez, Selenay Furat, Kubra Kavram Sarihan, Fatma Ceyla Eraldemir, Huseyin Askin Akpulat, Deniz Sahin, Sule Yildiz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive sciences (Thousand Oaks, Calif.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zeynep Ece Utkan KorunDepartment of Obstetrics and Gynecology, Yeditepe University Kozyatagi Hospital, Istanbul, Turkey.ORCID 0000-0002-1595-569X
Semil Selcen GocmezFaculty of Medicine, Department of Pharmacology, Kocaeli University, Kocaeli, Turkey.ORCID 0000-0001-7341-4907
Selenay FuratInstitute of Health Sciences, Department of Stem Cell, Kocaeli University, Kocaeli, Turkey.ORCID 0000-0002-0501-1679
Kubra Kavram SarihanFaculty of Dentistry, Department of Basic Medical Sciences, Kocaeli Health and Technology University, Kocaeli, Turkey.ORCID 0000-0001-9973-8619
Fatma Ceyla EraldemirFaculty of Medicine, Department of Biochemistry, Kocaeli University, Kocaeli, Turkey.ORCID 0000-0001-9410-8554
Huseyin Askin AkpulatFaculty of Education, Department of Biology, Sivas Cumhuriyet University, Sivas, Turkey.ORCID 0000-0001-8394-2746
Deniz SahinFaculty of Medicine, Department of Physiology, Kocaeli University, Kocaeli, Turkey.ORCID 0000-0002-6752-0065
Sule YildizFaculty of Medicine, Department of Obstetrics and Gynecology, Koç University, Istanbul, Turkey. yildizsuledr@gmail.com.ORCID 0000-0002-4803-7043

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alchemilla vulgaris has traditionally been used to treat gynecologic diseases. The anti-inflammatory and vasorelaxant effects of the extract of A. vulgaris (AVE) have been reported in previous studies. This study aimed to investigate the effects of A. vulgaris on PCOS, one of the most common metabolic disorders in adult women of reproductive age, accompanied by inflammation and vascular endothelial dysfunction, in an experimental animal model. Three groups of prepubertal female Wistar rats were established: PCOS, Control, and PCOS + AVE groups. Subcutaneous dehydroepiandrosterone (DHEA) was administered for 35 days to the PCOS and PCOS + AVE groups. The rats in the PCOS + AVE group were orally administered AVE (50 mg/100 g bw/day) for 35 days. Systemic blood pressure, vascular endothelial function, ovarian morphology, and endocrine biomarker levels were measured at the end of the experiment. TNF-α levels were also evaluated in the thoracic aorta and ovaries. Hormonal imbalances, ovarian morphological changes, and endothelial dysfunction were observed in the PCOS group, which returned to the controls after AVE treatment. Furthermore, AVE attenuated the aortic and ovarian levels of TNF-α in the PCOS group. Our study suggests that AVE may have beneficial effects in the treatment of PCOS due to its anti-inflammatory and vasculoprotective properties.

Indexed as

DehydroepiandrosteroneOvaryPlant ExtractsPolycystic Ovary SyndromeAnimalsDisease Models, AnimalEndothelium, VascularFemaleRatsRats, WistarTumor Necrosis Factor-alphaDehydroepiandrosteronePlant ExtractsTumor Necrosis Factor-alphaAlchemilla vulgarisİnflammationPolycystic ovary syndromeThoracic aortaVascular function

Identifiers

PMID40550985
PMCPMC12270970

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.