Evidence map›Paper›PMID 40550971›Full record

ArticleNature chemistry2025

Adaptive dynamic kinetic resolution enables alteration of chiral induction with ring sizes.

Bangkui Yu, Yao Huang, Haocheng Zhang, Hanmin Huang

Abstract read
PubMed Publisher
In one paragraph

Article in Nature chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Bangkui YuState Key Laboratory of Precision and Intelligent Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, P. R. China.ORCID http://orcid.org/0009-0004-0013-396X
Yao HuangState Key Laboratory of Precision and Intelligent Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, P. R. China.
Haocheng ZhangState Key Laboratory of Precision and Intelligent Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, P. R. China.ORCID http://orcid.org/0000-0002-2209-3629
Hanmin HuangState Key Laboratory of Precision and Intelligent Chemistry and Department of Chemistry, University of Science and Technology of China, Hefei, P. R. China. hanmin@ustc.edu.cn.ORCID http://orcid.org/0000-0002-0108-6542

Funding

National Natural Science Foundation of China (National Science Foundation of China) 21925111
6 · The paper itself

Abstract

Dynamic kinetic resolution (DKR) is an efficient chiral induction strategy that transforms both enantiomers of the substrate racemates into the same optically enriched product. Typically, the absolute configurations of the products should be determined by the chiral catalyst. Here we report an adaptive DKR strategy that forges diverse azapolycycles with high stereochemical selectivities by taking full advantage of the dynamic interconversion of diastereomeric aminoalkyl cyclopalladated complexes. Notably, this innovative adaptive DKR model achieves alterations of absolute configurations at the contiguous stereocentres with the same chiral diphosphine-ligated palladium catalyst by changing the ring sizes of the annulation products. Moreover, a concise and efficient total synthesis of martinellic acid was carried out by using the adaptive DKR process as the key chirality forging and scaffold establishment step, which further demonstrated the efficacy of this strategy.

Identifiers

PMID40550971

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.