Evidence map›Paper›PMID 40550967›Full record

Trial reportObesity surgery2025

Transcranial Magnetic Stimulation for Reducing Food Reinforcement in Patients Pursuing Metabolic Bariatric Surgery: A Within-Participants Sham-Controlled Pilot Trial.

Dale S Bond, Pavlos K Papasavas, Hollie A Raynor, Carlos M Grilo, Yin Wu, Dongyu Kang, Vaughn R Steele

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Obesity surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dale S BondHartford HealthCare Digestive Health Institute Center for Obesity Research, Innovation, and Education, Hartford, CT, USA. Dale.Bond@hhchealth.org.
Pavlos K PapasavasHartford HealthCare Digestive Health Institute Center for Obesity Research, Innovation, and Education, Hartford, CT, USA.
Hollie A RaynorDepartment of Nutrition, College of Education, Health, and Human Sciences, University of Tennessee, Knoxville, TN, USA.
Carlos M GriloDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yin WuHartford HealthCare Digestive Health Institute Center for Obesity Research, Innovation, and Education, Hartford, CT, USA.
Dongyu KangDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Vaughn R SteeleDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.

Funding

SUBSTANCE ABUSEK12DA000167 · NIDA · YALE UNIVERSITY · PI STEPHANIE S O'MALLEY, Marc N Potenza · 1991 to 2026
$17.7M
Cognitive-Behavioral and Pharmacologic Treatment of Binge Eating DisorderR01DK114075 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2018 to 2022
$3.6M
Using a SMART Design to Examine Pharmacological and Behavioral Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes after Metabolic and Bariatric SurgeryR01DK126637 · NIDDK · YALE UNIVERSITY · PI GRILO, CARLOS M · 2020 to 2025
$3.4M
Neuroimaging predictors of bariatric surgical outcomesR01DK113408 · NIDDK · HARTFORD HOSPITAL · PI PAPASAVAS, PAVLOS, PEARLSON, GODFREY D · 2018 to 2022
$3.3M
Modulating Temporoparietal Junction Mentalizing-Related Activity in Autism Spectrum Disorder using Transcranial Magnetic StimulationR01MH132044 · NIMH · HARTFORD HOSPITAL · PI Michal Assaf, Vaughn R Steele · 2023 to 2026
$3.1M
Translating basic habituation research to childhood obesity treatmentR01DK121360 · NIDDK · UNIVERSITY OF TENNESSEE KNOXVILLE · PI RAYNOR, HOLLIE A · 2019 to 2023
$2.8M
Using Acceptance and Commitment Therapy to Promote Autonomous Motivation for Increased Physical Activity and Improved Weight Loss Maintenance in Bariatric Surgery Patients: A Randomized TrialR01DK135463 · NIDDK · HARTFORD HOSPITAL · PI Dale S Bond, JASON LILLIS · 2024 to 2026
$1.7M
NIDA NIH HHS K12 DA000167NIDDK NIH HHS R01 DK113408NIDDK NIH HHS R01DK113408NIDDK NIH HHS R01 DK114075NIDDK NIH HHS R01 DK121360NIDDK NIH HHS R01 DK126637NIDDK NIH HHS R01 DK135463NIMH NIH HHS R01 MH132044
6 · The paper itself

Abstract

Individuals who undergo metabolic bariatric surgery (MBS) and have high preoccupation with and drive to consume palatable foods are at risk of overeating and suboptimal outcomes after MBS. Repetitive transcranial magnetic stimulation (rTMS), a non-invasive brain stimulation technique, shows promise for altering cognitive aspects of food reward. Yet, no study has examined rTMS effects on behavioral aspects of food reward in the context of MBS. This preliminary investigation administered rTMS to the left dorsolateral prefrontal cortex (using Montreal Neurological Institution coordinates of - 50, 30, 36) to reduce the relative-reinforcing value of food (RRV-i.e., how much effort an individual is willing to expend to obtain food compared to other rewards) in preoperative MBS patients. On separate testing days, participants completed an RRV task that compared how hard they would work for food versus money before and after random, counterbalanced assignment to active- or sham-rTMS. Higher RRV scores indicated a greater willingness to work for food relative to money. Of 12 participants randomized, 10 (40% male, 47.9 ± 4.8 years old; BMI = 45.1 ± 5.1 kg/m

Indexed as

Bariatric SurgeryFeeding BehaviorObesity, MorbidReinforcement, PsychologyTranscranial Magnetic StimulationAdultFemaleFoodHumansMaleMiddle AgedPilot ProjectsRewardTreatment OutcomeFoodFood reinforcementHedonic hungerNeuromodulationObesity

Identifiers

PMID40550967
PMCPMC12359249

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.