Evidence map›Paper›PMID 40550956›Full record

ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2025

Fatty acid amide hydrolase in major depressive episodes: A [

Dorsa Rafiei, Michelle De Pol, Jeffrey H Meyer, Kimberly Desmond, Ruth Ross, Isabelle Boileau, Jerry Warsh, Pablo Rusjan, Neil Vasdev, Ryan Aloysius and 2 more

Abstract read
In one paragraph

Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. PET imaging of FAAH in chronic Cannabis users: longitudinal assessment during short-term abstinence.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  2. Article
  3. Quantification of [Frontiers in neuroscience · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dorsa Rafiei *Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Michelle De Pol *Brain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Jeffrey H MeyerBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada. jeffrey.meyer@utoronto.ca.ORCID http://orcid.org/0000-0003-4684-5052
Kimberly DesmondBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Ruth RossDepartment of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
Isabelle BoileauBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID http://orcid.org/0000-0002-9901-1484
Jerry WarshBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Pablo RusjanDouglas Research Centre, McGill University, Montreal, QC, Canada.ORCID http://orcid.org/0000-0003-0075-2918
Neil VasdevBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Ryan AloysiusBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Lauren GrayBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada.
Nathan J KollaBrain Health Imaging Centre, Campbell Family Mental Health Research Institute, The Centre for Addiction and Mental Health, Toronto, ON, Canada. nkolla@swin.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role of the endocannabinoid system (ECS) in major depressive disorder (MDD) is under-investigated despite reports of increased activity and/or concentration of fatty acid amide hydrolase (FAAH), a key ECS enzyme, in fronto-limbic brain regions in some animal models of depressive behavior. We hypothesized that [

Indexed as

AmidohydrolasesApathyEndocannabinoidsMajor Depressive DisorderAdultBenzamidesCarbamatesCase-Control StudiesFatty Acid Amide HydrolasesFemaleGenotyping TechniquesGyrus CinguliHippocampusHumansMaleMiddle AgedAmidohydrolasesBenzamidesCarbamatescyclohexyl carbamic acid 3'-carbamoylbiphenyl-3-yl esterEndocannabinoidsFatty Acid Amide Hydrolases

Identifiers

PMID40550956
PMCPMC12339711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.