Evidence map›Paper›PMID 40550921›Full record

ArticleCellular & molecular immunology2025

Dermal adipogenesis protects against neutrophilic skin inflammation during psoriasis pathogenesis.

Tian Xia, Wenlu Zhang, Rundong Wu, Xiaowei Zhang, Rongshuang Xia, Xiao Hu, Shuai Wu, Yanhang Liao, Jiacheng Li, Youxi Liu and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular & molecular immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Tian Xia *State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Wenlu Zhang *State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Rundong Wu *State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Xiaowei ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Rongshuang XiaState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Xiao HuState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.ORCID 0009-0004-7516-9473
Shuai WuState Key Laboratory of Cellular Stress Biology, School of Biological Sciences, Xiamen University, Xiamen, 361102, China.
Yanhang LiaoState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Jiacheng LiState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Youxi LiuState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Yiman LiuState Key Laboratory of Cellular Stress Biology, School of Biological Sciences, Xiamen University, Xiamen, 361102, China.
Zhuolin GuoDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Chi ZhangState-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Department of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361102, China.
Wenjie LiuState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China.
Ming ChenState-Province Joint Engineering Laboratory of Marine Bioproducts and Technology, Department of Marine Biological Science & Technology, College of Ocean & Earth Sciences, Xiamen University, Xiamen, 361102, China.
Jiajing LuDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Yuling ShiDepartment of Dermatology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.
Ling-Juan ZhangState Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen, 361102, China. lingjuan.zhang@xmu.edu.cn.ORCID 0000-0001-6937-4578

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82373879Natural Science Foundation of Fujian Province (Fujian Provincial Natural Science Foundation) 2024J011009
6 · The paper itself

Abstract

The immune response of the skin to danger signals involves rapid recruitment of neutrophils, but their excessive accumulation leads to inflammatory skin diseases, such as psoriasis; however, the mechanisms governing their initiation and resolution are poorly understood. Here, we revealed a dynamic immunoregulatory role of dermal white adipose tissue (dWAT) in the progression and resolution of neutrophilic skin inflammation in an imiquimod-induced psoriasis mouse model. During inflammation onset, dWAT repopulates PDGFRA

Indexed as

AdipogenesisDermisInflammationNeutrophilsPsoriasisSkinAdipocytesAdipose Tissue, WhiteAnimalsDisease Models, AnimalFibroblastsHumansInterleukin-1betaMiceMice, Inbred C57BLPPAR gammaInterleukin-1betaPPAR gammaAdipocytesAdipogenesisFibroblastsNeutrophilsPsoriasisSkin inflammation

Identifiers

PMID40550921
PMCPMC12311125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.