ArticleScientific reports2025
Green and white analytical approach for parallel quantification of gabapentin and methylcobalamin in medicinal products using inventive RP-HPLC technique.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Simultaneous Determination of Three Residual Monomers in Polyvinyl Alcohol Eye Drops Using a Dual-Wavelength RP-HPLC Method and Evaluation of Its Greenness.Biomedical chromatography : BMC · 2026Article
- Determination of worst-case cephalosporin residues in laboratory glassware using a validated low-level RP-HPLC method.Scientific reports · 2026Article
- AQbD-driven RP-HPLC method for complete resolution of pantoprazole regioisomeric impurities with integrated multi-dimensional sustainability assessment.BMC chemistry · 2026Article
- Eco-optimized RP-HPLC method for chiral tazobactam and piperacillin drugs: integration with Box-Behnken design and multi-sustainability tools.Scientific reports · 2026Article
- Article
- Evaluation of six eco-analytical tools for the sustainable HPLC analysis of a quinary anti-cold drug mixture.Scientific reports · 2026Article
- A highly aqueous HPLC-PDA method for the assay of gabapentin and pregabalin: applications in pharmaceutical analysis, dissolution testing, and forensic screening.Frontiers in chemistry · 2026Article
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Authors and funding
6 authors.
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Abstract
A simple, selective, and environmentally sustainable RP-HPLC method was developed for simultaneous quantification of gabapentin (GAB) and Methylcobalamin (MET) in pharmaceutical products. Separation was achieved on a Zorbax Eclipse C8 column (150 × 4.6 mm, 3.5 μm) using a green mobile phase of potassium phosphate buffer (pH 6.9)/acetonitrile (95:5 v/v) at 2.0 mL/min, with detection at 210 nm. Total analysis time was 10 min with 100 µL injection volume. The method showed excellent linearity (3-50 µg/mL; R² > 0.9998), LODs (0.60-0.80 µg/mL), and LOQs (2.00-2.50 µg/mL). Environmental sustainability was validated by multiple metrics: AGREE (0.70), AGREEprep (0.71), and Analytical Eco-Scale (80), confirming superior greenness. Forced degradation studies demonstrated stability-indicating capability per ICH guidelines. This eco-friendly approach provides a reliable solution for quality control of GAB/MET formulations while minimizing environmental impact.
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