Evidence map›Paper›PMID 40550844›Full record

Observational studyJournal of perinatology : official journal of the California Perinatal Association2025

Early parenteral lipid intake supports cerebellar neurometabolism at term-age in preterm infants.

Sudeepta K Basu, Katherine M Ottolini, Kushal J Kapse, Julius Ngwa, Steve C N Hui, Nickie Andescavage, Jonathan Murnick, Adre J du Plessis, Catherine Limperopoulos

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sudeepta K BasuNeonatology, Children's National Hospital, Washington, DC, USA.ORCID http://orcid.org/0000-0002-9887-8764
Katherine M OttoliniNeonatology, Children's National Hospital, Washington, DC, USA.ORCID http://orcid.org/0000-0002-2674-7888
Kushal J KapseDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA.
Julius NgwaDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA.
Steve C N HuiDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA.ORCID http://orcid.org/0000-0002-1523-4040
Nickie AndescavageNeonatology, Children's National Hospital, Washington, DC, USA.
Jonathan MurnickThe George Washington University School of Medicine, Washington, DC, USA.
Adre J du PlessisThe George Washington University School of Medicine, Washington, DC, USA.
Catherine LimperopoulosDeveloping Brain Institute, Children's National Hospital, Washington, DC, USA. climpero@childrensnational.org.ORCID http://orcid.org/0000-0003-1735-0069

Funding

Clinical and Translational Science Institute at Childrens NationalUL1TR001876 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI BELL, MICHAEL J · 2016 to 2021
$25.6M
Child Health Research Career Development Award (CHRCDA) Program at Children's NationalK12HD001399 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI NATHAN KUPPERMANN · 2001 to 2026
$9.1M
Research_ProjectU54HD090257 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI GIOIA, GERARD A. · 2016 to 2020
$5.9M
Antecedents of Impaired Brain Development in Fetuses with Heart DiseaseR01HL116585 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI LIMPEROPOULOS, CATHERINE · 2013 to 2017
$3.8M
Impaired Brain Development in a Premature Ex-utero EnvironmentR01HD099393 · NICHD · CHILDREN'S RESEARCH INSTITUTE · PI DU PLESSIS, ADRE JACQUES, LIMPEROPOULOS, CATHERINE · 2020 to 2024
$3.4M
Clinical and Translational Science Institute at Childrens National-Mentored Career Development CoreKL2TR001877 · NCATS · CHILDREN'S RESEARCH INSTITUTE · PI LUBAN, NAOMI L · 2016 to 2020
$2.0M
NCATS NIH HHS KL2 TR001877NCATS NIH HHS UL1 TR001876NHLBI NIH HHS R01 HL116585NICHD NIH HHS K12 HD001399NICHD NIH HHS R01 HD099393NICHD NIH HHS U54 HD090257U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 1R01HD099393-01A1U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS) UL1TR001876 and KL2TR001877U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) 1R01HL116585
6 · The paper itself

Abstract

objectivesThe impact of crucial early parenteral nutrition on neurometabolism of the preterm brain remains unclear. This study characterizes the relationship of parenteral lipid and caloric intake with cerebellar neurometabolites.

methodsVery premature infants [born ≤32-week gestational age (GA)] in a prospective observational cohort study underwent a proton magnetic resonance spectroscopy (

results48 preterm infants born at 28.3 ± 2.4 weeks GA underwent

conclusionsParenteral lipid intake is associated with higher cerebellar NAA and Glx concentrations, supporting brain development in preterm infants.

Indexed as

Aspartic AcidCerebellumEnergy IntakeInfant, PrematureParenteral NutritionFemaleGestational AgeGlutamic AcidHumansInfant, NewbornMaleProspective StudiesProton Magnetic Resonance SpectroscopyAspartic AcidGlutamic AcidN-acetylaspartate

Identifiers

PMID40550844
PMCPMC12717006

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.