Evidence map›Paper›PMID 40550788›Full record

ArticleJournal of medicinal chemistry2025

New Generation Modified Azole Antifungals against Multidrug-Resistant

Yiyuan Chen, Yunxiao Li, Kazi S Nahar, Md Mahbub Hasan, Caleb Marsh, Melanie Clifford, Godwin A Aleku, Steven L Kelly, David C Lamb, Chengetai Diana Mpamhanga and 5 more

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yiyuan ChenInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Yunxiao LiInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Kazi S NaharInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Md Mahbub HasanInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Caleb MarshCountermeasures, Development, Evaluation and Preparedness, UK Health Security Agency, Manor Farm Road, Salisbury SP4 0JG, United Kingdom.ORCID 0000-0002-0265-0221
Melanie CliffordCountermeasures, Development, Evaluation and Preparedness, UK Health Security Agency, Manor Farm Road, Salisbury SP4 0JG, United Kingdom.
Godwin A AlekuInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.ORCID 0000-0003-0969-5526
Steven L KellyCentre for Cytochrome P450 Biodiversity, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, SA2 8PP, United Kingdom.
David C LambCentre for Cytochrome P450 Biodiversity, Faculty of Medicine, Health and Life Science, Swansea University, Swansea, SA2 8PP, United Kingdom.
Chengetai Diana MpamhangaSchool of Life Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AE, United Kingdom.ORCID 0000-0002-6897-259X
Ilias KounatidisSchool of Life Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AE, United Kingdom.
Ajit J ShahDepartment of Natural Sciences, University of Middlesex, The Burroughs, Hendon, London NW4 4BT, United Kingdom.
Charlotte K HindCountermeasures, Development, Evaluation and Preparedness, UK Health Security Agency, Manor Farm Road, Salisbury SP4 0JG, United Kingdom.ORCID 0000-0002-3763-3106
J Mark SuttonInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Khondaker Miraz RahmanInstitute of Pharmaceutical Science, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.ORCID 0000-0001-8566-8648

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rise of antifungal resistance and limited treatment options highlight the urgent need for new drug classes.

Indexed as

Antifungal AgentsAzolesCandidaCandida aurisDrug Resistance, Multiple, FungalAnimalsBiofilmsCandidiasisDrosophila melanogasterMicrobial Sensitivity TestsMothsStructure-Activity RelationshipAntifungal AgentsAzoles

Identifiers

PMID40550788
PMCPMC12257509

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.