Evidence map›Paper›PMID 40550722›Full record

ArticleBMJ open2025

Protocol for 'Re: CBT Dialysis': a realist evaluation-why, for whom and in what circumstances does cognitive behaviour therapy work for people with depressive symptoms receiving dialysis?

Kara Schick-Makaroff, Richard Sawatzky, Joanne Greenhalgh, Daniel Cukor, Hubert Wong, Scott Klarenbach, Charlotte Berendonk, Loretta Lee, Katrin Micklitz, Lori Suet Hang Lo and 1 more

Abstract read
In one paragraph

Article in BMJ open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. How Are People Undergoing Dialysis Expected to Benefit From Cognitive Behavioural Therapy? A Realist Analysis.Health expectations : an international journal of public participation in health care and health policy · 2025
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kara Schick-MakaroffFaculty of Nursing, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0001-6200-3416
Richard SawatzkySchool of Nursing, Trinity Western University, Langley, British Columbia, Canada rick.sawatzky@twu.ca.ORCID http://orcid.org/0000-0002-8042-190X
Joanne GreenhalghSchool of Sociology and Social Policy, University of Leeds, Leeds, UK.ORCID http://orcid.org/0000-0003-2189-8879
Daniel CukorDepartment of Medicine, Nephrology Division; Department of Psychiatry, NYU Grossman School of Medicine, New York City, New York, USA.
Hubert WongFaculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.ORCID http://orcid.org/0000-0001-8840-4509
Scott KlarenbachFaculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-8611-1056
Charlotte BerendonkFaculty of Nursing, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0003-4979-6866
Loretta LeePatient Partner, Edmonton, Alberta, Canada.
Katrin MicklitzFaculty of Nursing, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-6465-0307
Lori Suet Hang LoFaculty of Nursing, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0002-2141-8778
Megan KennedyGeoffrey & Robyn Sperber, Health Sciences Library, University of Alberta, Edmonton, Alberta, Canada.ORCID http://orcid.org/0000-0003-2337-6441

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionNearly 40% of adults receiving life-saving dialysis for kidney failure report depressive symptoms. With more than 40 000 Canadians on dialysis, this is a significant health burden. Cognitive behavioural therapy (CBT) has been shown to be effective for treating depressive symptoms; however, it is rarely considered or used for people receiving dialysis. The aim of this realist study is to evaluate and explain how, why, for whom and in what circumstances therapist-guided and remotely delivered CBT works in order to provide equitable mental healthcare to individuals with depressive symptoms receiving dialysis. METHODS AND ANALYSIS: The project will include a realist synthesis, a quantitative cohort study and a realist evaluation. Realist methodology is a theory-driven approach that seeks to explain how generative mechanisms are shaped by contextual features, giving rise to outcome patterns. We will begin by developing an initial programme theory (IPT) from the literature and interviews with CBT therapists to understand how CBT is intended to work and for whom. We will use data from the quantitative cohort study to identify contexts that may shape outcome patterns in CBT for people receiving dialysis. This includes previously collected survey data and data from a longitudinal cohort study, both sourced from people across Canada undergoing dialysis. We will test and refine the IPT using data from a realist evaluation and existing literature. The realist evaluation will involve participants from the quantitative cohort study who received therapist-guided, remotely delivered CBT. ETHICS AND DISSEMINATION: Ethical approvals have been granted. We have planned a wide range of dissemination strategies: journal manuscripts and conference presentations, executive memos for administrators of renal programmes in Canada, an online inventory of resources for depressive symptoms and presentations of findings together with patient partners at all participating sites. PROSPERO REGISTRATION NUMBER: CRD42023476184.

Indexed as

Cognitive Behavioral TherapyDepressionKidney Failure, ChronicRenal DialysisCanadaHumansResearch DesignDepression & mood disordersDialysisPsychological StressPsychosocial Intervention

Identifiers

PMID40550722
PMCPMC12186041

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.