ArticleTobacco control2025
Effects of oral nicotine pouches on cigarette smoking behaviour and tobacco harm exposure: a randomised pilot trial in adults.
Article in Tobacco control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04250727 (Switching to a Non-tobacco-based Oral Nicotine Product Among Adult Cigarette Smokers), which is not on this map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Switching to a Non-tobacco-based Oral Nicotine Product Among Adult Cigarette Smokers: Exploring the Roles of Product Characteristics and User History
Who cites it
6 citing papers in PubMed.
- Switching from Cigarettes to E-Cigarettes and Oral Nicotine Pouches in Adults with Low-Income Who Smoke: Qualitative Findings from a Pilot Randomized Controlled Trial.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Trial
- Factors associated with considering switching to nicotine pouches among US adults who smoke.Drug and alcohol dependence reports · 2026Article
- Patterns and characteristics of nicotine pouch use among adults with a history of cigarette smoking.Frontiers in public health · 2026Article
- Patterns and Perception of Nicotine Pouches Use Among Adults in Saudi Arabia.Tobacco use insights · 2026Article
- Nicotine pouches, oral cancer and tobacco harm reduction: current evidence and research priorities.Frontiers in oral health · 2026Review
- Testing oral nicotine pouches versus nicotine replacement therapy for cigarette harm reduction in Appalachia: The ARISE study protocol.PloS one · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Oral nicotine pouches may have potential for smoking cessation, but scientific evidence on the effects of pouches and their constituents on smoking behaviour is limited.
designThis study was a 4-week, open-label, randomised pilot trial of nicotine pouches in 3 mg (low) or 6 mg (high) nicotine strength. SUBJECTS: US outpatient research clinic with non-treatment seeking adults who smoke cigarettes (N=30).
interventionsParticipants selected two flavours and were instructed to switch to using nicotine pouches in place of cigarettes.
main outcome measuresWe compared groups on cigarettes smoked per day, pouch use and urinary levels of a tobacco-specific carcinogen (NNAL) over 4 weeks, biochemically verified 7-day point prevalence smoking abstinence at week 4, and willingness to continue pouch use.
resultsNearly all participants completed the trial (29/30). Participants in both groups significantly reduced their cigarettes smoked per day (log-transformed) over time (F
conclusionsResults provide preliminary support for nicotine pouches for cigarette substitution. Compared with lower nicotine strength pouches, higher nicotine strength pouches may have a greater impact on smoking behaviour and adults who smoke may be more willing to use them. TRIAL REGISTRATION NUMBER: NCT04250727.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.