ArticleEuropean journal of dentistry2026
Hydrogel and Injectable Platelet-Rich Fibrin: A Synergistic Approach to Osteogenesis.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Recent Advances in Natural Polymers-based Hydrogels for Periodontal Regeneration.Macromolecular bioscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Objective: Injectable platelet-rich fibrin (i-PRF) features a higher concentration of growth factor and lower viscosity compared with PRF, making it advantageous for periodontal regenerative therapy. However, its low mechanical property and high degradation rate cause its limited usage in bone augmentation. Hydrogel interacts with i-PRF, which is expected to replace bone graft considering its disadvantages. Through the synergistic effects of the materials, a sustained release of growth factor is achieved, promoting bone formation and maturation. Materials and Methods: Osteogenic markers, including alkaline phosphatase (ALP) activity and calcium deposition, were measured at intervals of 1, 7, 14, and 21 days using osteoblast-like cells. In vivo study using the extraction socket of Wistar rat applied with the same material was also done and measured at 21 and 42 days. The study included three groups: hydrogel i-PRF, bone graft (FDBA) i-PRF, and a control (blank hydrogel) group. Measurements utilized ALP staining and Alizarin red S assays for the in vitro study and bone dimension for the in vivo study. Results: Hydrogel i-PRF significantly enhanced ALP activity on days 7 and 14 compared with the bone graft i-PRF and control groups ( Conclusion: Hydrogel with i-PRF exhibits improved osteogenic capability compared with bone grafts, showing promise as an alternative material for periodontal regenerative applications.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.