Evidence map›Paper›PMID 40550479›Full record

ArticleInternational journal of laboratory hematology2025

How Trustworthy is Light Transmittance Platelet Aggregometry With Low Platelet Count Samples? Insights From Test Replicates and Retrospective Analysis of Several Decades of Diagnostic Samples.

Catherine P M Hayward, Rabab Al Dawood, Lindsay Wice, Karen A Moffat

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Article in International journal of laboratory hematology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Catherine P M HaywardDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.ORCID https://orcid.org/0000-0002-2843-0817
Rabab Al DawoodDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.
Lindsay WiceSpecial Coagulation Laboratory, Hamilton Regional Laboratory Medicine Program, Hamilton, Canada.
Karen A MoffatDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada.ORCID https://orcid.org/0000-0002-6431-5525

Funding

McMaster University
6 · The paper itself

Abstract

introductionLight transmission platelet aggregometry (LTA) is useful to diagnose platelet function disorders (PFD). We evaluated the precision and reproducibility of LTA with low platelet count platelet-rich plasma (LPRP).

methodsLPRP maximal aggregation (MA) precision for informative agonists and LTA reproducibility were assessed using multiple replicates for adjusted control LPRP (CLPRP) and retrospective analysis of several decades of consecutive patient LPRP (PLPRP) and CLPRP tests with replicates between and/or within tests.

resultsIntra-subject CLPRP had acceptable MA CVs and tracings unless platelets were ≤ 25 × 10

conclusionsDiagnostic LTA with LPRP has acceptable precision and reproducibility when evaluated with informative agonists. Nonetheless, caution is warranted when testing samples with ≤ 25 × 10

Indexed as

Blood Platelet DisordersBlood PlateletsPlatelet AggregationPlatelet Function TestsFemaleHumansMaleMiddle AgedPlatelet CountPlatelet-Rich PlasmaReproducibility of ResultsRetrospective Studiesplatelet aggregationplatelet function teststhrombocytopenia

Identifiers

PMID40550479
PMCPMC12597866

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.