Evidence map›Paper›PMID 40550474›Full record

ArticleNature2025

Gating and noelin clustering of native Ca

Chengli Fang, Cathy J Spangler, Jumi Park, Natalie Sheldon, Laurence O Trussell, Eric Gouaux

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Efficient and rapid isolation of native AMPA receptor complexes for cryo-EM.Protein science : a publication of the Protein Society · 2026
    Article
  9. Review
  10. Neuron-glioma synaptic transmission amplified by free 19S proteasome-mediated AMPAR deubiquitination promotes tumor progression.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chengli FangVollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0000-0002-8483-7902
Cathy J SpanglerVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Jumi ParkVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Natalie SheldonVollum Institute, Oregon Health and Science University, Portland, OR, USA.ORCID 0009-0008-4832-9688
Laurence O TrussellVollum Institute, Oregon Health and Science University, Portland, OR, USA.
Eric GouauxVollum Institute, Oregon Health and Science University, Portland, OR, USA. gouauxe@ohsu.edu.ORCID 0000-0002-8549-2360

Funding

NCCAT: National Center for CryoEM Access and Training- Supplement for Windows 10 and FFIU24GM129539 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI DE MARCO, ALEX, KIEFT, JEFFREY S · 2018 to 2023
$53.9M
NCCAT: National Center for CryoEM Access and TrainingR24GM154192 · NIGMS · NEW YORK STRUCTURAL BIOLOGY CENTER · PI EDWARD T ENG, Jeffrey S Kieft · 2024 to 2026
$21.0M
Synaptic mechanisms in the auditory system (Administrative Supplement)R01DC004450 · NIDCD · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 1999 to 2026
$10.6M
3D STRUCTURE/FUNCTION OF LIGAND GATED ION CHANNELSR01NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI GOUAUX, JAMES E · 1999 to 2024
$6.7M
3D Structure and Function of Ligand-Gated Ion ChannelsR37NS038631 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI James E Gouaux · 2009 to 2026
$4.1M
Regulation of axonal and synaptic signaling in interneuron (supplement)R35NS116798 · NINDS · OREGON HEALTH & SCIENCE UNIVERSITY · PI LAURENCE O TRUSSELL · 2020 to 2026
$4.1M
Characterization of native AMPA receptor structure and function in glioblastomaK00CA253730 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SPANGLER, CATHERINE JEANETTE · 2022 to 2025
$409k
Structure-Guided Mechanistic Studies of Dot1L in Mixed Lineage LeukemiaF99CA253730 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SPANGLER, CATHERINE JEANETTE · 2020 to 2021
$76k
NCI NIH HHS F99 CA253730NCI NIH HHS K00 CA253730NIDCD NIH HHS R01 DC004450NIGMS NIH HHS R24 GM154192NIGMS NIH HHS U24 GM129539NINDS NIH HHS R01 NS038631NINDS NIH HHS R35 NS116798NINDS NIH HHS R37 NS038631
6 · The paper itself

Abstract

AMPA-type ionotropic glutamate receptors (AMPARs) are integral to fast excitatory synaptic transmission and have vital roles in synaptic plasticity, motor coordination, learning and memory

Indexed as

CalciumCryoelectron MicroscopyIon Channel GatingReceptors, AMPAAnimalsMaleModels, MolecularProtein SubunitsRatsCalciumProtein SubunitsReceptors, AMPA

Identifiers

PMID40550474
PMCPMC12422955

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.