ArticleAmerican journal of ophthalmology2025
Three-Dimensional Mechanical Characterization of Normal, Subclinical, and Keratoconic Corneas Using Motion Tracking Brillouin Microscopy.
Article in American journal of ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Comparative Diagnostic Efficacy of Swept-Source OCT and Scheimpflug Imaging in Clinically Unaffected Eyes of Very Asymmetric Ectasia.Ophthalmology science · 2026Article
- Motion-Tracking Brillouin Microscopy for Keratoconus Suspect Identification: Comparison With Multimodal Corneal Imaging.American journal of ophthalmology · 2026Article
- Wavelet time-frequency analysis enhances noise-resilient quantification of corneal wave velocity and natural frequency in optical coherence elastography.Biomedical optics express · 2026Article
- Quantitative assessment of the biomechanical properties of healthy human myopic corneas using Brillouin spectroscopy.BMC ophthalmology · 2026Article
- Brillouin microscopy in cancer research: a review.Journal of biomedical optics · 2025Review
- Focal Weakening/Thinnest Corneal Point Proximity in Normal, Subclinical, and Keratoconic Corneas Using Motion-Tracking Brillouin Microscopy.Ophthalmology scienceArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
purposeTo characterize the 3-dimensional (3-D) mechanical differences between normal corneas and those with subclinical keratoconus (SKC) or clinical keratoconus (KC) using motion-tacking (MT) Brillouin microscopy.
designProspective cross-sectional study.
methodsThere were 50 eyes from 50 patients evaluated, including 20 Control eyes from 20 patients, 20 SKC eyes from 20 patients, and 10 stage I or II KC eyes from 10 patients. All patients had Scheimpflug imaging for group classification and MT Brillouin microscopy using a custom-built device for mechanical evaluation. Mean and minimum MT Brillouin shift values were generated in the anterior, middle, and posterior stromal regions. Receiver operating characteristic (ROC) curves were generated for MT Brillouin metrics to determine the area under the ROC curve (AUROC), sensitivity, and specificity for each variable at each location.
resultsThere were no significant differences between groups for age, sex, or mean keratometry. There were significant differences between control, SKC, and KC groups for all MT Brillouin metrics, with greatest differences in anterior min (Δ 43-57 MHz, P < .001) and Mean (Δ 34-37 MHz, P < .001), middle min (Δ 44-69 MHz, P < .001) and Mean (Δ 39-54 MHz, P < .001), and least differences in posterior min (Δ 15-22 MHz, P < .001) and Mean (Δ 20-32 MHz, P < .001). Anterior min values fully separated both SKC and KC groups from controls (AUC = 1.0 for each), while anterior mean (AUC = 0.98, 1.0), middle mean (AUC = 0.96, 1.0), and middle min (AUC = 0.94, 1.0) performed better than posterior mean (AUC = 0.81, 0.95) or posterior min (AUC = 0.78, 0.88).
conclusionsMT Brillouin microscopy identified 3-dimensional differences between controls eyes and those with subclinical or early-stage keratoconus. Differences were most pronounced in the anterior stroma and least pronounced in the posterior stroma, indicating relevant axial mechanical differences in eyes with SKC. NOTE: Publication of this article is sponsored by the American Ophthalmological Society.
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