Evidence map›Paper›PMID 40550405›Full record

ArticleNeuroImage2025

Unsupervised single-image super-resolution for infant brain MRI.

Cheng Che Tsai, Xiaoyang Chen, Sahar Ahmad, Pew-Thian Yap

Abstract read
In one paragraph

Article in NeuroImage, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cheng Che TsaiDepartment of Computer Science, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Xiaoyang ChenDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sahar AhmadDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Pew-Thian YapDepartment of Radiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: ptyap@med.unc.edu.

Funding

Longitudinal Mapping of Human Brain Development in the First Years of LifeR01EB008374 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2009 to 2024
$5.1M
Computational Diffusion MRI for Studying Early Human Brain DevelopmentR01MH125479 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2021 to 2025
$2.1M
Optimized High-Resolution Fast Magnetic Resonance Fingerprinting with Cloud-Based ReconstructionR01NS134849 · NINDS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Yong Chen, Pew-Thian Yap · 2024 to 2026
$1.9M
Comprehensive MR Fingerprinting for Infants and Young Children at Risk for Developmental Delays.R01HD112923 · NICHD · DUKE UNIVERSITY · PI Dan Ma, DEANNE E WILSON-COSTELLO · 2024 to 2026
$1.7M
Multifaceted Characterization of Early Human Brain DevelopmentR01MH133836 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI YAP, PEW-THIAN · 2024 to 2025
$1.2M
AI-Powered MRI Quality Control and Artifact Correction for Multi-Site StudiesR01EB035160 · NIBIB · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Pew-Thian Yap · 2024 to 2026
$1.2M
NIBIB NIH HHS R01 EB008374NIBIB NIH HHS R01 EB035160NICHD NIH HHS R01 HD112923NIMH NIH HHS R01 MH125479NIMH NIH HHS R01 MH133836NINDS NIH HHS R01 NS134849
6 · The paper itself

Abstract

Acquiring high-resolution (HR) MR images of infant brains is challenging due to lengthy scan times and limited subject compliance. Image super-resolution (SR) techniques can generate HR images from low-resolution (LR) inputs, reducing the need for extended acquisitions. However, most existing SR methods require HR images for training, limiting their practical use in real-world scenarios. To overcome this limitation, we propose an unsupervised single-image SR approach that requires only a single LR image for training. By integrating image space regularity with k-space consistency, our method enhances training stability and mitigates overfitting. Additionally, we introduce joint self-supervised learning to improve the fidelity of low-frequency content in the generated images. Our approach demonstrates both quantitative and qualitative improvements in MRI resolution for infants aged 1 week to 1 year, offering robust performance without manual hyperparameter tuning across diverse inputs. This innovation enables fully automated, high-throughput MRI resolution enhancement, addressing a critical need in pediatric neuroimaging.

Indexed as

BrainImage Processing, Computer-AssistedMagnetic Resonance ImagingNeuroimagingUnsupervised Machine LearningFemaleHumansInfantInfant, NewbornMaleInfant brain MRITrustworthy reconstructionUnsupervised single-image super-resolution

Identifiers

PMID40550405
PMCPMC12277040

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.