Evidence map›Paper›PMID 40550289›Full record

ArticleJournal of pain and symptom management2025

Profoundly Depleted: Qualitative Study of Persistent Fatigue Following Hematopoietic Cell Transplant.

Ashley M Nelson, Katherine G Cronin, Ally M Wood, Lara Traeger, Anna Barata, Richard Newcomb, Hermioni L Amonoo, Heather S L Jim, Hans Knoop, Areej El-Jawahri and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pain and symptom management, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ashley M NelsonMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA; Harvard Medical School (A.M.N., A.B., R.N., H.L.A., A.E.J., J.A.G.), Boston, Massachusetts, USA. Electronic address: anelson11@mgh.harvard.edu.
Katherine G CroninMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA.
Ally M WoodMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA.
Lara TraegerMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA; University of Miami (L.T.), Coral Gables, Florida, USA.
Anna BarataMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA; Harvard Medical School (A.M.N., A.B., R.N., H.L.A., A.E.J., J.A.G.), Boston, Massachusetts, USA.
Richard NewcombMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA; Harvard Medical School (A.M.N., A.B., R.N., H.L.A., A.E.J., J.A.G.), Boston, Massachusetts, USA.
Hermioni L AmonooHarvard Medical School (A.M.N., A.B., R.N., H.L.A., A.E.J., J.A.G.), Boston, Massachusetts, USA; Brigham and Women's Hospital (H.L.A.), Boston, Massachusetts, USA; Dana-Farber Cancer Institute (H.L.A.), Boston, Massachusetts, USA.
Heather S L JimMoffitt Cancer Center (H.S.L.J.), Tampa, Florida, USA.
Hans KnoopUniversity of Amsterdam (H.K.), Amsterdam, The Netherlands.
Areej El-JawahriMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA; Harvard Medical School (A.M.N., A.B., R.N., H.L.A., A.E.J., J.A.G.), Boston, Massachusetts, USA.
Joseph A GreerMassachusetts General Hospital (A.M.N., K.G.C., A.M.W., L.T., A.B., R.N., A.E.J., J.A.G.), Boston, Massachusetts, USA; Harvard Medical School (A.M.N., A.B., R.N., H.L.A., A.E.J., J.A.G.), Boston, Massachusetts, USA.

Funding

Reducing Persistent Fatigue Following Hematopoietic Stem Cell TransplantationK23HL159328 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NELSON, ASHLEY · 2021 to 2025
$870k
NHLBI NIH HHS K23 HL159328
6 · The paper itself

Abstract

contextFatigue is the most commonly-reported symptom during long-term survivorship after hematopoietic cell transplant (HCT).

objectivesWe sought to describe how HCT recipients experience and manage persistent post-transplant fatigue and to identify patient perceptions of and preferences for fatigue support.

methodsHCT recipients who were at least six months after autologous or allogeneic HCT and experiencing moderate to severe fatigue based on the fatiue symptom inventory (severity rating ≥4 / 0-10 scale) participated in this qualitative study conducted at a tertiary care transplant center. Participants completed in-depth individual interviews using semi-structured guides that probed their experiences with persistent fatigue. We simultaneously interviewed a small sample of five HCT clinicians. We used thematic analysis to code verbatim transcripts for a priori and identified themes.

resultsParticipants (N = 20; median (range) age = 55 (31-78) years; n = 9 female) were a median of 3.88 years (6 months-13 years) post-transplant and reported moderate fatigue severity (median = 5 (4-9)/0-10 scale). Final themes included: 1) challenges describing the multidimensional symptom of persistent fatigue, 2) fatigue as an impairing ongoing symptom, 3) identification of a variety of factors modulating persistent fatigue, 4) use of action- and emotion-oriented strategies to manage fatigue, and 5) desire for additional information and fatigue support.

conclusionStudy findings highlight the numerous and ongoing disruptions to everyday life experienced by patients living with persistent fatigue following HCT, variety of management strategies, and their desire for supportive programs to aid in the management of this symptom. Results support the need for future research into evidence-based interventions to alleviate HCT survivors' fatigue.

Indexed as

FatigueHematopoietic Stem Cell TransplantationAdultAgedFemaleHumansMaleMiddle AgedQualitative ResearchFatiguehematopoietic stem cell transplantationqualitative researchquality of lifesurvivorship

Identifiers

PMID40550289
PMCPMC12993725

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.