ArticleJournal of behavioral addictions2025
Individual-specific subspace of altered functional connectivity predicts clinical symptoms in Internet gaming disorder.
Article in Journal of behavioral addictions, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Despite extensive research efforts aimed at unraveling the neural mechanisms underlying Internet gaming disorder (IGD), reproducibility remains a challenge, largely due to overlooking the clinical and biological diversity within individuals affected by IGD. Therefore, investigating the altered brain features associated with IGD within both individual-shared and individual-specific subspaces is crucial for understanding this complex and heterogeneous disorder. Methods: This study included 555 participants, comprising 326 individuals with IGD and 229 recreational game users (RGUs). Firstly, we computed altered functional connectivity (AFC) matrices for individuals with IGD and compared them with those of RGUs. Subsequently, we applied the common orthogonal basis extraction algorithm to partition the AFC of individuals with IGD into individual-shared and individual-specific subspaces. Finally, we examined brain regions exhibiting generally abnormal patterns in the individual-shared subspace and employed multiple linear regression analysis to assess the predictive influence of AFC within the individual-specific subspace on clinical symptoms. Results: Our findings revealed individual-shared altered patterns in the visual network, medial frontal network (MFN), and frontoparietal network (FPN) among individuals with IGD, which are associated with executive control and visual processing. Within the individual-specific subspace, we observed that AFC within the default mode network could predict scores related to fun-seeking behavior in the behavioral activation system (BAS), while AFC within the MFN correlated with reward responsiveness and drive scores in the BAS. Additionally, AFC within the FPN was predictive of scores in the behavioral inhibition system. Conclusions: This study successfully decomposed the AFC of IGD into individual-shared and individual-specific subspaces. The AFC within individual-specific subspaces holds promise as potential biomarkers for elucidating clinical symptoms in IGD, thereby offering an analytical framework for investigating heterogeneity in other addictive behaviors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.