Evidence map›Paper›PMID 40549921›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2025

The role of estrogen receptor β in maintaining basal cells and modulating the immune environment in the prostate.

Wan-Fu Wu, Xiao-Yu Song, Margaret Warner, Otabeck Imamov, Per Antonson, Jan-Ake Gustafsson

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. RUNX1T1 drives stem-like small-cell neuroendocrine prostate cancer identity.Frontiers in cell and developmental biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Wan-Fu WuCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204.ORCID 0000-0002-2231-9528
Xiao-Yu SongCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204.ORCID 0000-0001-9485-977X
Margaret WarnerCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204.
Otabeck ImamovTiohundra AB Norrtälje Regional Hospital, Department of Surgery and Urology, Norrtälje 761 29, Sweden.
Per AntonsonCenter for Innovative Medicine, Department of Biosciences and Nutrition, Karolinska Institutet, Novum, Stockholm 14186, Sweden.
Jan-Ake GustafssonCenter for Nuclear Receptors and Cell Signaling, Department of Biology and Biochemistry, University of Houston, Houston, TX 77204.ORCID 0000-0002-1472-1373

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Estrogen receptor β (ERβ) plays an important role in both the mouse and human prostate. The endogenous ligand for ERβ is the dihydrotestosterone metabolite, 5β-androstane-3β, 17β-diol (3β-Adiol). Thus, treatment with 5-α reductase inhibitor (5-ARI) should produce a phenotype similar to that seen in ERβ

Indexed as

Estrogen Receptor betaProstateAnimalsHomeodomain ProteinsHumansMaleMiceMice, KnockoutProstatic HyperplasiaReceptors, AndrogenSignal TransductionTrans-ActivatorsTranscription FactorsTumor Suppressor ProteinsAR protein, mouseEstrogen Receptor betaHomeodomain ProteinsNkx3-1 protein, mouseReceptors, AndrogenTrans-ActivatorsTranscription FactorsTrp63 protein, mouseTumor Suppressor ProteinsBPHnuclear receptorprogenitor cellprostate cancertreatment

Identifiers

PMID40549921
PMCPMC12232695

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.