Evidence map›Paper›PMID 40549831›Full record

SynthesisAnnals of medicine2025

Does pneumonia increase the risk of dementia and cognitive decline? A systematic review and meta-analysis.

Zhen Yan, Min Zhang, Lifang Yu, Fulian Zhang

Abstract readSystematic ReviewMeta-Analysis
In one paragraph

Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Zhen YanDepartment of Critical Care Support Ward, Hangzhou Geriatric Hospital, Hangzhou, Zhejiang, China.
Min ZhangDepartment of Critical Care Support Ward, Hangzhou Geriatric Hospital, Hangzhou, Zhejiang, China.
Lifang YuDepartment of Critical Care Support Ward, Hangzhou Geriatric Hospital, Hangzhou, Zhejiang, China.
Fulian ZhangDepartment of Critical Care Support Ward, Hangzhou Geriatric Hospital, Hangzhou, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe link between pneumonia and elevated risk of dementia and cognitive decline is still unclear. This study aims to evaluate the link between pneumonia and the subsequent risk of developing dementia.

methodsMEDLINE (

resultsTen studies were included, encompassing a diverse population sample. Pooled analysis demonstrated a significant correlation between pneumonia and increased risk of dementia (HR = 1.738; 95% CI: 1.358 to 2.225), with substantial heterogeneity across the studies (I

conclusionsThis meta-analysis suggests that pneumonia is associated with a significantly higher risk of developing dementia. These findings underscore the need for diligent monitoring and preventive strategies for patients recovering from pneumonia, particularly among the elderly, to mitigate potential cognitive decline.PROSPERO registration number: CRD42024520631.

Indexed as

Cognitive DysfunctionDementiaPneumoniaAgedHumansMaleRisk FactorsDementiameta-analysisolder adultspneumonia

Identifiers

PMID40549831
PMCPMC12931307

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.