Evidence map›Paper›PMID 40549756›Full record

ArticlePloS one2025

Clinical impact of low bone mineral density in patients with colorectal cancer liver metastasis undergoing hepatectomy.

Yuichi Aoki, Atsushi Miki, Yasunaru Sakuma, Jun Watanabe, Takehiro Kagaya, Makiko Tahara, Takumi Teratani, Kazuhiro Endo, Hideki Sasanuma, Wataru Nishimura and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuichi AokiDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Atsushi MikiDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.ORCID 0000-0002-2908-0177
Yasunaru SakumaDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Jun WatanabeDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Takehiro KagayaDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.ORCID 0000-0001-6637-9568
Makiko TaharaDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Takumi TerataniDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.ORCID 0000-0001-9923-0305
Kazuhiro EndoDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Hideki SasanumaDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Wataru NishimuraDivision of Cell Biology and Anatomy, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.ORCID 0000-0002-8068-1277
Hisanaga HorieDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Joji KitayamaDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.
Naohiro SataDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.ORCID 0000-0002-6689-5623
Hironori YamaguchiDepartment of Surgery, Division of Gastroenterological, General and Transplant Surgery, Jichi Medical University, Yakushiji, Shimotsuke, Tochigi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to elucidate the clinical impact of osteopenia on the recurrence of colon cancer liver metastases.

methodsPatients with colon cancer liver metastases (N = 186) undergoing hepatectomy at Jichi Medical University Hospital between March 2006 and March 2020 were examined retrospectively. Computed tomography (CT) scans on the 11th vertebra within 3 months of surgery assessed bone mineral density (BMD). Age-adjusted BMD determined osteopenia presence. Kaplan-Meier method with a log-rank test estimated survival. Factors associated with survival were assessed using Cox's proportional hazards model after adjustment for confounders.

resultsPatients with osteopenia had shorter overall (p = 0.0001; 5-year overall survival, 51.8% vs 81.8%) and recurrence-free survival (p = 0.0008, 5-year recurrence-free survival: 26.3% vs 51.5%) than BMD-normal patients. In multivariable analysis, the risk factor for overall survival was osteopenia (Hazard ratio (HR) 3.79, 95% confidence interval (CI) 2.09-6.87, p = 0.001). Risk factors for recurrence were chemotherapy (HR 1.92, 95%CI 1.12-3.30, p = 0.002), tumor number (HR 1.51, 95%CI 1.02-2.27, p = 0.04), and osteopenia (HR 2.18, 95%CI 1.46-3.24 p = 0.001). Patients with osteopenia are more likely to develop lung metastases, and BMD-value reduction associated with KRAS mutation.

conclusionOsteopenia may have prognostic significance in patients with liver metastases colorectal cancer.

Indexed as

Bone DensityBone Diseases, MetabolicColorectal NeoplasmsHepatectomyLiver NeoplasmsAdultAgedFemaleHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm Recurrence, LocalRetrospective StudiesRisk FactorsTomography, X-Ray Computed

Identifiers

PMID40549756
PMCPMC12184893

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.