Evidence map›Paper›PMID 40549561›Full record

ArticleAmerican journal of physiology. Heart and circulatory physiology2025

Expression and function of β-site amyloid precursor protein-cleaving enzyme 2 in vascular endothelium.

Livius V d'Uscio, Tetiana Kovalenko, Tongrong He, Trace A Christensen, Jeffrey L Salisbury, Zvonimir S Katusic

Abstract read
In one paragraph

Article in American journal of physiology. Heart and circulatory physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Livius V d'UscioDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.ORCID 0000-0001-9577-9480
Tetiana KovalenkoDepartment of Neurology, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.ORCID 0000-0002-6866-5979
Tongrong HeDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.
Trace A ChristensenMicroscopy and Cell Analysis Core Facility, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.ORCID 0000-0003-4862-6259
Jeffrey L SalisburyMicroscopy and Cell Analysis Core Facility, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.
Zvonimir S KatusicDepartment of Anesthesiology and Perioperative Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, United States.ORCID 0000-0001-7016-7883

Funding

Role of endothelium in pathogenesis of cerebral amyloid angiopathyR01AG071190 · NIA · MAYO CLINIC ROCHESTER · PI KATUSIC, ZVONIMIR S · 2021 to 2025
$3.2M
HHS | NIH | National Institute on Aging (NIA) AG071190Mayo Foundation for Medical Education and Research (MFMER)NIA NIH HHS R01 AG071190
6 · The paper itself

Abstract

The physiological function of β-site amyloid precursor protein-cleaving enzyme 2 (BACE2) in vascular endothelium of systemic arteries is unknown. In the present study, we generated conditional tamoxifen-inducible endothelial BACE2-deficient mice (

Indexed as

Amyloid Precursor Protein SecretasesAortaAspartic Acid EndopeptidasesEndothelial CellsEndothelium, VascularVasodilationAnimalsCyclooxygenase 2FemaleMaleMiceMice, Inbred C57BLMice, KnockoutNitric Oxide Synthase Type IIIThromboxane A2Vasodilator AgentsAmyloid Precursor Protein SecretasesAspartic Acid EndopeptidasesCyclooxygenase 2Nitric Oxide Synthase Type IIIThromboxane A2Vasodilator Agentsendothelial functionendothelial nitric oxide synthaseprostanoidsthromboxane A2β-site amyloid precursor protein-cleaving enzyme 2

Identifiers

PMID40549561
PMCPMC12286421

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.