Evidence map›Paper›PMID 40549505›Full record

ArticleDiabetes2025

Subclasses of Glucose Trajectories in Early Childhood Stratified the Risk of Abnormal Glucose Tolerance in Adolescence and Young Adulthood.

Yingchai Zhang, Eric S H Lau, Claudia H T Tam, Noel Y H Ng, Mai Shi, Atta Y T Tsang, Hanbin Wu, Aimin Yang, Hongjiang Wu, Lai Yuk Yuen and 7 more

Abstract read
In one paragraph

Article in Diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yingchai ZhangDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0001-5092-4859
Eric S H LauDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-1581-5643
Claudia H T TamDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-9169-0013
Noel Y H NgDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-4186-7113
Mai ShiDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-2798-3268
Atta Y T TsangDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0009-0007-4132-7084
Hanbin WuDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0001-6076-7703
Aimin YangDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-2968-1762
Hongjiang WuDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-2193-1114
Lai Yuk YuenDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-2249-1077
Elaine Y K ChowDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-4147-3387
Andrea O Y LukDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-5244-6069
Alice P S KongDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0001-8927-6764
Chi Chiu WangLi Ka Shing Institute of Health Sciences, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-3928-7278
Juliana C N ChanDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-1325-1194
Wing Hung TamDepartment of Obstetrics and Gynaecology, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0003-1189-740X
Ronald C W MaDepartment of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong SAR, People's Republic of China.ORCID 0000-0002-1227-803X

Funding

Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up StudyU01DK094830 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI METZGER, BOYD E · 2012 to 2016
$18.6M
Hyperglycemia and Adverse Pregnancy Outcome (HAPO)R01HD034243 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI METZGER, BOYD E · 1999 to 2010
$16.2M
HAPO: DATA COORDINATING CENTERR01HD034242 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DYER, ALAN R · 1999 to 2007
$3.0M
Chinese University of Hong Kong grants CUHK 473408, 471713, 14118316, 14118718, 14Council of the Hong Kong SAR, China 14102719Council of the Hong Kong SAR, China 14118316Council of the Hong Kong SAR, China 14118718Council of the Hong Kong SAR, China 471713Council of the Hong Kong SAR, China CUHK 473408Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentNational Institute of Child Health and Human DevelopmentNICHD NIH HHS R01 HD034242NICHD NIH HHS R01 HD034243NIDDK NIH HHS 1U01DK094830NIDDK NIH HHS R01-HD34242NIDDK NIH HHS R01-HD34243NIDDK NIH HHS U01 DK094830
6 · The paper itself

Abstract

article highlightsAbnormal glucose tolerance (AGT) in youth has become an alarming global public health issue; however, approaches to identify high-risk population among young people have not been well-established. Can the long-term risk of AGT be stratified by the subclasses of glucose trajectories defined in childhood? Subclasses defined in childhood can efficiently stratify the risk of AGT in adolescence and young adulthood. The subclass membership was strongly associated with cardiometabolic disorders in childhood and maternal cardiometabolic disorders during pregnancy. This subclass method provides a potential strategy to identify those at risk of later cardiometabolic disorders from childhood for more intensive evaluation of intervention. The close relationship between maternal cardiometabolic disorders and subclass membership of children highlighted the potential influence of gestational cardiometabolic health on the development of cardiometabolic disorders in offspring.

Indexed as

Blood GlucoseGlucose IntoleranceAdolescentChildFemaleGlucose Tolerance TestHumansMalePregnancyPrenatal Exposure Delayed EffectsRisk FactorsYoung AdultBlood Glucose

Identifiers

PMID40549505
PMCPMC12365413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.