Evidence map›Paper›PMID 40549329›Full record

ReviewInfection2025

Congenital syphilis: adverse pregnancy outcomes and neonatal disorders.

Baihuan Duan, Yuefang Zhou, Xinyi Wang, Huiqiao Wang, Yan Li, Xiang Zhou, Yujun Tang, Chenbin Zhu, Peng Liu, Jiaofeng Peng

Abstract readReview
PubMed Publisher
In one paragraph

Review in Infection, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Baihuan DuanInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Yuefang ZhouInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Xinyi WangInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Huiqiao WangInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Yan LiInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Xiang ZhouInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Yujun TangPlastic surgery department, the second hospital university of South China, Hengyang, 421001, China.
Chenbin ZhuClinical lab, Hengyang Chinese Medicine Hospital, Hengyang, 421001, Hunan, China.
Peng LiuInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China.
Jiaofeng PengInstitute of Pathogenic Biology and Key Laboratory of Special Pathogen Prevention and Control of Hunan Province, Hengyang Medical College, University of South China, Hengyang Central Hospital, Hengyang, China. pengjf0901@163.com.

Funding

Guidance Plan Project of Hengyang City, China 2424017529Natural Science Foundation of Hunan Province, China 2023JJ30503The Scientific Research Foundation of Hunan Provincial Education Department, China 22A0297
6 · The paper itself

Abstract

Treponema pallidum (T. pallidum) poses a significant hazard to the health of both expectant mothers and neonates. The bacterium can be transmitted via the placenta from an infected mother to the fetus during pregnancy. Congenital syphilis may occur if the infant is exposed to the infection through contact with the mother's body fluids after delivery. The symptoms of congenital syphilis can severely compromise a newborn's health. In addition to various pathological anomalies, affected children may face skin, bone, internal organ, and nervous system issues. These complications can lead to long-term developmental delays, cognitive impairments, and increased risk of infections. Early detection and treatment are crucial to mitigate these risks and promote healthier outcomes for both the infant and the mother. The worldwide prevalence of congenital syphilis is escalating, rising from 203 cases per 100,000 in 2015 to 295 cases per 100,000 in 2021. The primary treatment for syphilis is currently penicillin G therapy, which produces reliable clinical efficacy. This review offers a thorough analysis of adverse pregnancy outcomes, including preterm birth, miscarriage, stillbirth, and neonatal disorders such as skin lesions and skeletal malformations. The aim is to foster the development of innovative preventive and early diagnostic strategies through a thorough analysis of diagnostic data. These initiatives are expected to reduce the number of affected children significantly, hence enhancing societal stability and safeguarding the health of mothers and infants.

Indexed as

Pregnancy Complications, InfectiousPregnancy OutcomeSyphilis, CongenitalFemaleHumansInfant, NewbornInfectious Disease Transmission, VerticalPregnancyTreponema pallidumAdverse pregnancyCongenital syphilisNeonatal defectsSexually transmitted diseasesTreponema pallidum

Identifiers

PMID40549329

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.