Evidence map›Paper›PMID 40549318›Full record

ArticleInflammopharmacology2025

Hibiscus sabdariffa L. (Roselle flower) extract exerts protective effects against lipopolysaccharide-induced inflammation by ameliorating TLR4/NF-κB and NLRP3 inflammasome activation.

Narongsuk Munkong, Atcharaporn Ontawong, Natthaphon Thatsanasuwan, Sirinat Pengnet, Jiradej Makjaroen, Phorutai Pearngam, Saharat Nanthawong, Poorichaya Somparn, Natnisha Leelahavanichkul, Arthid Thim-Uam

Abstract read
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Article in Inflammopharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Narongsuk MunkongDepartment of Pathology, School of Medicine, University of Phayao, Phayao, 56000, Thailand.
Atcharaporn OntawongDivision of Physiology, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Natthaphon ThatsanasuwanDivision of Nutrition, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Sirinat PengnetDivision of Physiology, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand.
Jiradej MakjaroenFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, 10400, Thailand.
Phorutai PearngamInternational College, Mahidol University, Nakhon Pathom, 73170, Thailand.
Saharat NanthawongFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, 10400, Thailand.
Poorichaya SomparnFaculty of Medicine, Center of Excellence in Systems Biology, Chulalongkorn University, Bangkok, 10400, Thailand.
Natnisha LeelahavanichkulFaculty of Medicine, Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Arthid Thim-UamDivision of Biochemistry, School of Medical Sciences, University of Phayao, Phayao, 56000, Thailand. Arthidth@gmail.com.ORCID http://orcid.org/0000-0002-1321-9728

Funding

the Thailand science research and innovation fund and the University of Phayao Grant No. FF66-RIM061
6 · The paper itself

Abstract

The phytochemical constituents of various plant extracts have shown potential in mitigating oxidative stress and inflammation. Hibiscus sabdariffa L. (HS), known as the roselle flower, has demonstrated antioxidant and anti-inflammatory effects in several models. Our study aimed to evaluate the effects of aqueous HS extract on modulating the TLR4/MyD88/NF-κB and Caspase-11/NLRP3 inflammasome signaling pathways during lipopolysaccharide (LPS)-induced mitochondrial stress and inflammation in macrophages by several in vitro assays. The results demonstrated that compared with LPS alone, HS extract significantly reduced the production of ROS, nitric oxide and proinflammatory cytokines (IL-6, TNF-α, PG-E2, IL-1β, and IFN-γ) by lowering the gene expression of p

Indexed as

HibiscusInflammasomesInflammationNLR Family, Pyrin Domain-Containing 3 ProteinPlant ExtractsAnimalsAnti-Inflammatory AgentsFlowersLipopolysaccharidesMacrophagesMiceNF-kappa BRAW 264.7 CellsSignal TransductionToll-Like Receptor 4Anti-Inflammatory AgentsInflammasomesLipopolysaccharidesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, mousePlant ExtractsTlr4 protein, mouseToll-Like Receptor 4Anti-inflammationHibiscus sabdariffa LinnM1/M2 macrophagesMitochondrial dysfunctionNLRP3 inflammasomeRoselle flower

Identifiers

PMID40549318

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.