Evidence map›Paper›PMID 40549302›Full record

ReviewDiscover oncology2025

Precision medicine research progress based on colorectal cancer organoids.

Xiyou Pang, Yuqing Hu, Zhihui Dai, Qiuwen Lou, Wenxia Xu, Lin Chen

Abstract readReview
In one paragraph

Review in Discover oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Anti-Metastatic Effects ofInternational journal of molecular sciences · 2025
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiyou PangDepartment of Anesthesiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China.
Yuqing HuCentral Laboratory, Precision Medicine Center, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China.
Zhihui DaiJinhua Key Laboratory of Cancer Nutrition and Metabolism Research, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China.
Qiuwen LouCentral Laboratory, Precision Medicine Center, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China.
Wenxia XuCentral Laboratory, Precision Medicine Center, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China. xuwenxia@zju.edu.cn.
Lin ChenCentral Laboratory, Precision Medicine Center, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, 321000, Zhejiang Province, China. lynne_1121@163.com.

Funding

Jinhua Science and Technology Research Program No. 2021-3-035Jinhua Science and Technology Research Program No.2023-3-111TCM science and technology program of Zhejiang Province No.2024ZL1183Zhejiang Provincial Natural Science Foundation of China No.LTGY23H160025
6 · The paper itself

Abstract

Organoids are cultures that use stem cells to induce differentiation or clinical samples as raw materials to form three-dimensional spatial structures through specific culture systems, thereby simulating the structure and function of tissues in vivo. Organoids are characterized by their ease of construction, long-term stable passage, clinical authenticity, and application in high-throughput drug screening. Patient-derived organoids have great application value in colorectal cancer research and individualized treatment. In this review, recent advances in colorectal cancer organoid culture technology, clinical individualized drug sensitivity assessment, new drug screening, drug mechanism research, nanomedicine-based applications, and imaging technology are summarized. These advancements will provide support for the precise diagnosis and treatment of colorectal cancer and the development of new treatment strategies, which will have significant scientific value and clinical transformation value.

Indexed as

Colorectal cancerDrug screeningOrganoidsPrecision medicine

Identifiers

PMID40549302
PMCPMC12185829

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.