ReviewMolecular biology reports2025
Dysregulation and gene polymorphisms of Vitamin D receptor: its implications in lipid metabolic disorders.
Review in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Effect of vitamin D receptor gene TaqI polymorphism on vitamin D levels and biochemical, inflammatory, and oxidative stress markers in individuals with obesity.Molecular biology reports · 2026Article
- Genetic Polymorphisms of Vitamin D Receptor and Immune-Metabolic Mechanisms in Recurrent Pregnancy Loss: Narrative Review.Biology · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intricate relationship between vitamin D and metabolic homeostasis has garnered substantial attention recently. The presence of the vitamin D receptor (VDR) in many tissues provides evidence of its broad physiological roles, in addition to its impact on calcium and phosphorus metabolism. VDR gene is expressed in various tissues such as skin, adipose tissue, testis, thyroid, esophagus, etc. Decreased VDR expression is associated with numerous complications such as muscle weakness, poor cancer prognosis, coronary restenosis, cognitive disability, susceptibility to autoimmune diseases, diabetes, and others. Conversely, overexpression of VDR can result in pathological conditions such as hypercalcemia, soft tissue calcification, kidney damage, cardiovascular complications, skeletal muscle hypertrophy, and cancer cell invasion and metastasis, leading to cancer cell proliferation. Therefore, it is crucial to maintain proper and balanced VDR expression, as both its downregulation and upregulation can lead to significant consequences. The genetic variants in the VDR gene, particularly ApaI (rs7975232), BsmI (rs1544410), FokI (rs2228570) and TaqI (rs731236), play a significant role in regulating lipid homeostasis. VDR gene polymorphisms are associated with several disease conditions such as inflammatory bowel disease, multiple sclerosis, pulmonary tuberculosis, asthma and gestational diabetes mellitus, in addition to lipid metabolic disorders. This review explores the emerging body of literature that sheds light on the dysregulation of VDR expression, VDR gene polymorphisms, and their implications in metabolic disorders, with a particular focus on lipid metabolism. With an emphasis on unraveling the molecular intricacies of this phenomenon, this review explores the multifaceted role of the VDR in key metabolic pathways and its potential involvement in lipid-associated conditions such as obesity, dyslipidemia, fatty liver disease, and atherosclerosis.
Indexed as
Identifiers
40549261What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.