Trial reportLasers in medical science2025
Combined extraoral and intraoral photobiomodulation for the prevention and management of oral mucositis and Xerostomia caused by the treatment of head and neck cancers.
Trial report in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed.
- Comparable efficacy of extraoral and intraoral photobiomodulation in preventing oral mucositis during high-dose methotrexate therapy in pediatric oncology: A single-blind randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Trial
- Effectiveness of Photobiomodulation as a Treatment for Xerostomia in Patients with Head and Neck Cancer Undergoing Radiotherapy: A Systematic Review and Meta-Analysis.Dentistry journal · 2026Review
- Photobiomodulation for salivary gland dysfunction: aligning clinical expectations with etiology-dependent treatment responsiveness.Lasers in medical science · 2026Review
- Comparative efficacy of two photobiomodulation protocols transcutaneous versus intraoral in the prevention of oral mucositis in head and neck cancer: a randomized study protocol.Lasers in medical science · 2026Article
- Clinical Efficacy and Safety of Photobiomodulation Therapy for Orofacial Conditions in Older Adults: A Systematic Review of Randomized Controlled Trials.Dentistry journal · 2026Review
- A Case Series on the Combined Use of Zinc L-Carnosine and Nd:YAG Photobiomodulation for Radiation-Induced Oral Mucositis: Pain Reduction and Lesion Improvement.Case reports in dentistry · 2026Article
- Photobiomodulation in the management of oral lesions: a targeted, evidence-based approach.Brazilian oral research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
purposeTo evaluate the effectiveness of combined intraoral and extraoral photobiomodulation (PBM) in the management of oral mucositis (OM) and xerostomia in patients undergoing head and neck cancer (HNC) treatment.
methodsSeventy-five patients with HNC were included and randomly assigned to 2 groups: those receiving intraoral PBM and a simulated extraoral PBM application (PBMI-SE group, n = 38); and those receiving combined intraoral and extraoral PBM (PBMIE group, n = 37). Quality of life related to OM and xerostomia, OM symptoms, OM grade, and salivary flow rate were assessed. Results were analyzed using the Kruskal-Wallis test (Student-Newman-Keuls).
resultsCombined intraoral and extraoral PBM led to a significant improvement in quality of life (OHIP-14, PROMS, and XeQOLS scores) compared with intraoral PBM alone (p < 0.001). From the second week onward, the PBMIE group experienced significantly lower OM grades (p < 0.001) than the PBMI-SE group. Additionally, the PBMIE group showed a significant improvement in both resting and stimulated sialometry from the second collection onward compared with the PBMI-SE group (p < 0.001).
conclusionCombined extraoral and intraoral PBM improved the quality of life of patients undergoing HNC treatment, particularly in relation to OM and xerostomia. This combined approach effectively controlled OM severity and improved salivary flow, offering a potential treatment option for these patients. CLINICAL
trial registrationThis study was registered in Brazilian Registry of Clinical Trials (ReBEC) (RBR-5p2xfzd). First Posted: October 03, 2023.
Indexed as
Identifiers
40549226What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.