ReviewPlanta2025
Strategies for increasing saikosaponins accumulation in Bupleurum: insights from environmental and microbial regulation.
Review in Planta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Using Biomod2 and spatial quality modeling for comprehensive production zoning ofFrontiers in plant science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
MAIN
conclusionSuitable environments (low light, drought, adequate nutrients, moderate salinity, low temperature) and microorganisms (endophytic fungi, AMF, Trichoderma) promote saikosaponins accumulation by regulating key enzymes and transcription factors in biosynthetic pathways. Saikosaponins (SSs) are the principal bioactive constituents and crucial quality control markers in the genus Bupleurum. They possess diverse pharmacological activities, such as sedation, antipyretic, anticonvulsant, anti-inflammation, antitumor, antiviral, and hepatoprotection. The biosynthesis and accumulation of SSs are influenced by multiple factors, including abiotic environmental conditions (e.g., water, soil, light, and temperature) and microbial factors (such as endophytic fungi, mycorrhizal fungi, Trichoderma fungi and bacteria). Enzymes involved in SSs biosynthesis (e.g., HMGR, FPPS, IPPI, β-AS, P450, UGT) and transcription factors (e.g., ERF1-1, bHLH14, NAC53, WRKY6, WRKY16, WRKY32, WRKY40, etc.) play a key role in promoting the accumulation of SSs by these abiotic factors and microorganisms. This paper summarizes the regulation of SSs accumulation by environmental factors and microbial factors, aiming to provide a scientific basis for increasing SSs content in the genus Bupleurum and for formulating effective regulatory strategies to utilize high-quality medicinal materials.
Indexed as
Identifiers
40549222What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.