Evidence map›Paper›PMID 40549207›Full record

ArticleEuropean journal of applied physiology2025

Brief extreme passive heat exposure leads to elevated biomarkers of systemic inflammation and acute kidney injury in older vs young adults.

Maria Vliora, James J McCormick, Kelli E King, Paraskevi Gkiata, Antonia Kaltsatou, Andreas D Flouris, Glen P Kenny

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Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Maria Vliora *FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece.
James J McCormick *Human and Environmental Physiology Research Unit, University of Ottawa, 125 University Private, Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada.
Kelli E KingHuman and Environmental Physiology Research Unit, University of Ottawa, 125 University Private, Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada.
Paraskevi GkiataFAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece.
Antonia KaltsatouFAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece.
Andreas D FlourisFAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece.
Glen P KennyHuman and Environmental Physiology Research Unit, University of Ottawa, 125 University Private, Room 367, Montpetit Hall, Ottawa, ON, K1N 6N5, Canada. gkenny@uottawa.ca.ORCID http://orcid.org/0000-0001-8683-6973

Funding

CIHR 399434CIHR PJT - 180242
6 · The paper itself

Abstract

purposeWith the advent of climate change, older adults are increasingly exposed to hot ambient temperatures that can lead to a state of heat-induced cytotoxicity contributing to heat-vulnerability. We assessed changes in serum proteins associated with indices of cellular stress in young and older adults exposed to extreme passive heat exposure.

methodsResponses were assessed in 19 young (23 ± 2.9 years; 5 female) and 27 older (62 ± 7.0 years; 2 female) adults exposed to a 3-h seated passive extreme heat exposure (44 °C, 30% relative humidity). Serum samples were assessed before and after heat exposure for proteins indicative of systemic inflammation (CRP, sCD14, TNF-α, and IL-6), intestinal permeability (IFABP), acute kidney injury (NGAL), and cytoprotection (irisin, klotho, and HSP70) via enzyme-linked immunosorbent assays.

resultsThe older group displayed significant elevations in CRP (18.06 ± 20.3 vs 24.3 ± 25.0 mg/mL, p < 0.002) in response to heat exposure that was not observed in the young group (both p > 0.999) although no changes in sCD14, TNF-α, or IL-6 occurred in either group. However, significant elevations in NGAL concentrations from baseline were observed in the older group (17.74 ± 23.65 vs 40.75 ± 58.18 ng/mL, p = 0.001), with no changes from baseline in the young group (p = 0.999). Conversely, klotho was significantly elevated after heat exposure in the young group (1346.37 ± 2242.49 vs 1129 ± 202 pg/mL, p = 0.017) but not in older adults (p > 0.999).

conclusionTaken together, older adults experienced some evidence of elevated inflammatory signaling and acute kidney injury that is accompanied by a blunted klotho response to extreme heat.

Indexed as

Acute Kidney InjuryExtreme HeatInflammationAdultAgedBiomarkersFemaleGlucuronidaseHumansInterleukin-6Klotho ProteinsLipocalin-2MaleMiddle AgedTumor Necrosis Factor-alphaYoung AdultBiomarkersGlucuronidaseInterleukin-6Klotho ProteinsKL protein, humanLipocalin-2Tumor Necrosis Factor-alphaAcute kidney injuryAgingCellular stress responseExtreme heatHeat shock proteinHeatwavesInflammationIntestinal permeability

Identifiers

PMID40549207

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.