Evidence map›Paper›PMID 40549177›Full record

ArticleExperimental brain research2025

Beta-band desynchronization in the human hippocampus during movement preparation in a delayed reach task.

Xiecheng Shao, Ryan S Chung, Shivani Sundaram, Roberto Martin Del Campo-Vera, Jonathon Cavaleri, Selena Zhang, Adith Swarup, Alexandra Kammen, Miguel Parra, Xenos Mason and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental brain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiecheng ShaoDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA. shaox@usc.edu.
Ryan S ChungDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Shivani SundaramDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Roberto Martin Del Campo-VeraDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Jonathon CavaleriDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Selena ZhangDepartment of Biomedical Engineering, Viterbi School of Engineering of USC, University of Southern California, Los Angeles, CA, USA.
Adith SwarupDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Alexandra KammenDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Miguel ParraDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Xenos MasonDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Christi HeckUSC Neurorestoration Center, Keck School of Medicine of USC, Los Angeles, CA, USA.
Charles Y LiuDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Spencer S KellisDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.
Brian LeeDepartment of Neurological Surgery, Keck School of Medicine of USC, University of Southern California, 1200 N State Street, Suite 3300, Los Angeles, CA, 90033, USA.

Funding

Decoding / encoding somatosensation from the hand area of the human primary somatosensory (S1) cortex for a closed-loop motor / sensory brain-machine interface (BMI)K23NS114190 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI LEE, BRIAN · 2020 to 2024
$950k
NINDS NIH HHS K23 NS114190
6 · The paper itself

Abstract

Though the hippocampus is known for its role in memory and navigation, growing evidence has suggested that it is involved in voluntary movement. By investigating whether the hippocampus is active during movement preparation, we can understand its role in motor control. In this study, we utilized a Delayed Reach task to measure beta-band (13-30 Hz) amplitude changes in the human hippocampus during movement preparation. We hypothesized to observe beta-band event-related desynchronization (ERD) during the movement preparation phases. Eleven patients diagnosed with drug-resistant epilepsy were implanted with stereoelectroencephalographic (SEEG) depth electrodes and SEEG signals were recorded. We pre-processed the raw neural signals using the zap-line noise removal technique and re-referenced the data using a novel weighted electrode shaft re-referencing technique. The beta-band Power Spectral Density (PSD) was calculated using multi-taper spectral analysis and trial averaged PSD between task phases was compared using a cluster-based permutation test. We then compared modulation between ipsilateral vs. contralateral contacts using the group-level Yate's z-test. 91% of participants and 46.8% of hippocampal gray matter contacts (n = 149) exhibited significant beta-band ERD during the Delay phase compared to baseline. During the Response phase, 100% of participants and 69.8% of hippocampal gray matter contacts exhibited significant beta-band decreases. We observed no significant difference between ipsilateral and contralateral contacts (p > 0.05). This study is the first to demonstrate hippocampal beta-band modulation during movement preparation, implying that the hippocampus may be involved during the movement processing.

Indexed as

Beta RhythmCortical SynchronizationHippocampusPsychomotor PerformanceAdultDrug Resistant EpilepsyElectrodes, ImplantedElectroencephalographyFemaleHumansMaleMiddle AgedMovementYoung AdultBeta-band powerDelayed reach taskHippocampusMovement planningNeural modulationStereotactic electroencephalography (SEEG)

Identifiers

PMID40549177
PMCPMC12185599

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.