Evidence map›Paper›PMID 40549120›Full record

ArticleJournal of neuro-oncology2025

Cesium-131 collagen tile brachytherapy for salvage of recurrent intracranial metastases.

Thomas H Beckham, Elaine E Cha, Michael K Rooney, Martin C Tom, Subha Perni, Mary Frances McAleer, Jing Li, Rajat J Kudchadker, Surendra Prajapati, Yana Zlateva and 6 more

Abstract read
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Article in Journal of neuro-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Observational
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas H Beckham *Department of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA. Thbeckham@mdanderson.org.
Elaine E Cha *Department of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Michael K RooneyDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Martin C TomDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Subha PerniDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Mary Frances McAleerDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Jing LiDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Rajat J KudchadkerDepartments of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Surendra PrajapatiDepartments of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Yana ZlatevaDepartments of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Diana KayaDepartments of Neuroradiology, The University of Texas MD Anderson Cancer Center, Neuroradiology, Houston, TX, USA.
Chibawanye I EneDepartments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Neurosurgery, Houston, TX, USA.
Sherise D FergusonDepartments of Neurosurgery, The University of Texas MD Anderson Cancer Center, Neurosurgery, Houston, TX, USA.
Jason T HuseDepartments of Anatomical Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Sujit S PrabhuDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.
Jeffrey S WeinbergDepartment of CNS Radiation Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeManagement of brain metastases (BM) that recur after stereotactic radiosurgery (SRS) (rBM) is challenging. We reviewed our experience with resection with Cs-131 collagen tile brachytherapy for rBM.

methodsPatients with rBM after SRS salvaged with resection and Cs-131 brachytherapy were reviewed. Analyses included descriptive statistics, Kaplan-Meier for overall survival (OS), Fine and Gray modeling for subgroup comparisons, and cumulative incidence of LF (CILF).

resultsThirty-one patients (38 surgical cavities) were reviewed; primaries were most commonly breast (37%) or non-small cell lung cancer (26%). All BMs had received prior SRS to a median 20 Gy in 1 fraction at a median 12.3 months before tile implantation; disease in 32 cavities (84%) was gross totally resected. At a median patient follow-up time of 11.8 months, LF developed in 6 of 38 cavities (16%); with CILF 7.9% at 6 months and 13% at 1 year. Risk factors for LF included > 1 prior radiation courses (HR 2.44; p = 0.001), subtotal resection (HR 6.99; p = 0.015), tumor volume (HR 1.04; p = 0.006), and degree of dural contact (p < 0.001). One-year OS rate was 65.8%. Three cavities (8%) among two patients (6%) developed grade 2 + radionecrosis. Two patients developed classical leptomeningeal disease (LMD) and two patients had nodular dural seeding for an overall incidence of LMD of 12.9%.

conclusionsSalvage resection with Cs-131 collagen tile brachytherapy for rBM after SRS provides favorable local control with minimal toxicity. Lesion characteristics may help to identify patients at increased risk for LF.

Indexed as

BrachytherapyBrain NeoplasmsCesium RadioisotopesCollagenNeoplasm Recurrence, LocalSalvage TherapyAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedRadiosurgeryRetrospective StudiesCesium-131Cesium RadioisotopesCollagenBrain MetastasesCesium-131Intracranial BrachytherapySalvage Therapy

Identifiers

PMID40549120

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.