Evidence map›Paper›PMID 40549026›Full record

ArticleActa neuropathologica2025

Transient receptor potential vanilloid channel 2 contributes to multi-modal endoplasmic reticulum and perinuclear space dilations that can also be observed in prion-infected mice.

Wenda Zhao, Shehab Eid, Chris Sackmann, Declan Williams, Xinzhu Wang, Yunqing Ouyang, Thomas Zerbes, Gerold Schmitt-Ulms

Abstract read
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In one paragraph

Article in Acta neuropathologica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wenda ZhaoTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Shehab EidTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Chris SackmannTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Declan WilliamsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Xinzhu WangTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Yunqing OuyangTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Thomas ZerbesTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada.
Gerold Schmitt-UlmsTanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, ON, Canada. g.schmittulms@utoronto.ca.

Funding

Canadian Institutes for Health Research 202209PJT
6 · The paper itself

Abstract

Our recent work on the prion protein and Na

Indexed as

BrainEndoplasmic ReticulumPrion DiseasesTRPV Cation ChannelsAnimalsDisease Models, AnimalHumansMiceMice, Inbred C57BLMice, TransgenicNeuronsSodium-Potassium-Exchanging ATPaseVacuolesSodium-Potassium-Exchanging ATPaseTRPV Cation ChannelsEndoplasmic reticulumNa+, K+-ATPasesPerinuclear spacePrion diseasesSpongiform degenerationTRPV2

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.