ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025
Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Bionic microneedles: Design inspired by bionics and its applications in medicine.International journal of pharmaceutics: X · 2026Review
- Evolution of 3D-Printed Microneedles toward Closed-Loop Theranostic Platforms.Research (Washington, D.C.) · 2026Review
- Interdisciplinarity traditional Chinese medicine microneedles in skin disease treatment: Recent advances and challenges.Bioactive materials · 2026Review
- Tetrazine-enhanced donor-acceptor-donor metal-organic frameworks for photodynamic antibacterial therapy and wound healing.Nature communications · 2025Article
- Decoding orofacial pain: a translational review of mechanisms and novel therapies.The journal of headache and pain · 2025Review
- Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Bacterial infectious stomatitis (BIS), characterized by severe infections overlaying ulcers, poses complex therapeutic challenges and often results in prolonged healing, leading to significant patient discomfort. To address this clinical challenge, a biomimetic microneedle (MN) suction cup is designed inspired by the tarsal claw of Drosophila. The suction cup component is crafted from polyvinyl alcohol (PVA) hydrogel, while the MN section, embedded within the suction cup, comprises a thermoresponsive and antibacterial composite hydrogel infused with the drug S-nitrosoglutathione (GSNO). This innovative design not only ensures strong adhesion to moist surfaces but also provides substantial antibacterial and anti-inflammatory effects, controlled drug release, active promotion of concentric wound contraction, and enhanced vasodilation, thereby facilitating rapid and comprehensive healing of BIS. The multifunctionality of the MN suction cup patch developed in this study represents a significant innovation over traditional treatment methods and holds potential for widespread application in dental clinics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.