Evidence map›Paper›PMID 40548932›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2025

CD74 Blockade Disrupts Endothelial Migrasome Signaling to Prevent Inflammatory Macrophage Differentiation and Inhibit Atherosclerotic Progression.

Kangnan Zhang, Jiong Chen, Zhenhua Zhu, Hong Hu, Qinghui Zhang, Rongrong Jia, Na Wang, Shihao Xiang, Yong Zhou, Yuehong Wang and 1 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Nanomaterials-Based Immunotherapy for Atherosclerosis.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Migrasomes in Ischemic Stroke: Molecular Landscape and Pathophysiological Impact.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Kangnan ZhangClinical Research Institue, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200080, China.
Jiong ChenDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200336, China.
Zhenhua ZhuKey Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Department of Pathophysiology, Shanghai Jiao Tong University School of Medicine (SJTU-SM), Shanghai, 200001, China.
Hong HuDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200336, China.
Qinghui ZhangDepartment of Clinical laboratory, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200336, China.
Rongrong JiaDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200336, China.
Na WangDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200336, China.
Shihao XiangDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200336, China.
Yong ZhouClinical Research Institue, Shanghai General Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200080, China.
Yuehong WangDepartment of Cardiology, 2nd Affiliated Hospital of Harbin Medical University, Harbin, 150001, China.
Ling XuDepartment of Gastroenterology, Tongren Hospital, Shanghai Jiao tong University School of Medicine, Shanghai, 200336, China.ORCID https://orcid.org/0000-0002-3438-8432

Funding

National Natural Science Foundation of China 82072642
6 · The paper itself

Abstract

Endothelial dysfunction and abnormal activation of the monocyte-macrophage system form a critical loop in atherosclerosis. The role of migrasomes in endothelial-immune interactions remains unclear. This study explores migrasome evolution in the atherosclerotic (AS) microenvironment, highlighting their function as amplifiers in the inflammatory cascade. Through analysis of ApoE

Indexed as

Antigens, Differentiation, B-LymphocyteAtherosclerosisCell DifferentiationEndothelial CellsHistocompatibility Antigens Class IIMacrophagesAnimalsDisease Models, AnimalDisease ProgressionHumansInflammationMiceMice, Inbred C57BLSignal TransductionAntigens, Differentiation, B-LymphocyteHistocompatibility Antigens Class IIinvariant chainAPP‐CD74atheroscleroticendothelial cellmacrophagemigrasome

Identifiers

PMID40548932
PMCPMC12463019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.