Evidence map›Paper›PMID 40548865›Full record

ArticleTissue engineering. Part C, Methods2025

Physiological Response of Tissue-Engineered Vascular Grafts to Vasoactive Agents in an Ovine Model.

Marissa Guo, Delaney Villarreal, Tatsuya Watanabe, Matthew Wiet, Anudari Ulziibayar, Adrienne Morrison, Kirsten Nelson, Satoshi Yuhara, Syed Faizullah Hussaini, Toshiharu Shinoka and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tissue engineering. Part C, Methods, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Marissa GuoCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Delaney VillarrealCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Tatsuya WatanabeCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.ORCID 0000-0002-1104-141X
Matthew WietCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Anudari UlziibayarCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Adrienne MorrisonCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Kirsten NelsonCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Satoshi YuharaCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Syed Faizullah HussainiCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Toshiharu ShinokaCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.
Christopher BreuerCenter for Regenerative Medicine, Research Institute at Nationwide Children's Hospital, Columbus, Ohio, USA.

Funding

A preclinical study evaluating and comparing the efficacy of tissue engineered vascular grafts to polytetrafluoroethylene grafts - DIVERSITY SUPP VILLARREALR01HL163065 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BREUER, CHRISTOPHER KANE · 2022 to 2025
$1.4M
Department of Defense W81XWH-22-1-0597NHLBI NIH HHS R01 HL163065
6 · The paper itself

Abstract

Tissue-engineered vascular grafts (TEVGs) are emerging as promising alternatives to synthetic grafts, particularly in pediatric cardiovascular surgery. While TEVGs have demonstrated growth potential, compliance, and resistance to calcification, their functional integration into the circulation, especially their ability to respond to physiological stimuli, remains underexplored. Vasoreactivity, the dynamic contraction or dilation of blood vessels in response to vasoactive agents, is a key property of native vessels that affects systemic hemodynamics and long-term vascular function. This study aimed to develop and validate an

Indexed as

Blood Vessel ProsthesisTissue EngineeringVasoconstrictor AgentsVasodilator AgentsVena Cava, InferiorAnimalsHemodynamicsModels, AnimalNitroprussideNorepinephrineSheepNitroprussideNorepinephrineVasoconstrictor AgentsVasodilator Agentsin vivo testingovine modelphysiological responsetissue-engineered vascular graftsvasoreactivity

Identifiers

PMID40548865
PMCPMC12409265

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.