Observational studyActa paediatrica (Oslo, Norway : 1992)2025
Younger Age and Viral Triggers Were Associated With Post-Infectious Bronchiolitis Obliterans in French Children.
Observational study in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Integrated multiomics reveals a clinically relevant CXCL8-centric protein network in pediatric postinfectious bronchiolitis obliterans.Respiratory research · 2026Article
- An Ex Vivo Model of Post Infectious Bronchiolitis Obliterans in Children Using Reconstituted Human Bronchial Epithelium.Biomolecules · 2026Article
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Authors and funding
25 authors.
Funding
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Abstract
aimPost-infectious bronchiolitis obliterans (PIBO) is a rare but severe chronic paediatric obstructive lung disease, characterised by the obliteration of small airways following severe lower respiratory tract infections. Epidemiological data in Europe remain limited.
methodsThis multicentre retrospective study examined the characteristics of paediatric patients diagnosed with PIBO from 2017 to 2023. Carried out by the French Reference Centre of Rare Lung Diseases network, it was based on clinical and radiological criteria and included age at diagnosis, medical history, symptoms, initial triggers, treatment, and outcomes.
resultsThe study comprised 147 patients (58.5% male) diagnosed by 18 tertiary centres at a median age of 22 months. Most (83.7%) were hospitalised for the suspected initial infection: 36.7% in intensive care units and 47.0% in acute care wards. A younger age at diagnosis was associated with higher hospitalisation rates (p = 0.01). Microbiological triggers were identified in 66.0%, mostly adenoviruses (28.5%) and the respiratory syncytial virus (26.4%), often as co-infections. Lung function tests were performed on 23.1% of patients and bronchoscopies on 66.9%. Treatment included inhaled corticosteroids (90.5%), azithromycin (59.2%) and intravenous corticosteroid pulses (40.8%).
conclusionAge and causative agents were key factors in the initial severity of the infection that led to paediatric PIBO in our study.
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