Evidence map›Paper›PMID 40548747›Full record

ArticlemSphere2025

Refinement of the Reference Viral Database (RVDB) for improving bioinformatics analysis of virus detection by high-throughput sequencing (HTS).

Pei-Ju Chin, Jaysheel D Bhavsar, Trent J Bosma, Madolyn L MacDonald, Shawn W Polson, Arifa S Khan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Pei-Ju ChinDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0001-8892-7465
Jaysheel D BhavsarCenter for Bioinformatics and Computational Biology, Department of Computer and Information Sciences, University of Delaware, Newark, Delaware, USA.ORCID 0009-0003-6174-4329
Trent J BosmaDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0003-2815-3423
Madolyn L MacDonaldCenter for Bioinformatics and Computational Biology, Department of Computer and Information Sciences, University of Delaware, Newark, Delaware, USA.ORCID 0000-0001-5590-1365
Shawn W PolsonCenter for Bioinformatics and Computational Biology, Department of Computer and Information Sciences, University of Delaware, Newark, Delaware, USA.ORCID 0000-0002-3398-6932
Arifa S KhanDivision of Viral Products, Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, Silver Spring, Maryland, USA.ORCID 0000-0002-5633-6131

Funding

Predictive Modeling & Optimal Control Framework for Model-Based Epidemic Response in DelawareP20GM103446 · NIGMS · UNIVERSITY OF DELAWARE · PI Anjana Narayan Bhat · 2012 to 2026
$67.2M
Data Management and Storage System for Shared Resource FacilitiesS10OD028725 · OD · UNIVERSITY OF DELAWARE · PI POLSON, SHAWN W · 2021 to 2021
$600k
Bill and Melinda Gates Foundation OPP1204996Delaware Biotechnology InstituteDelaware IDeA Network of Biomedical Research Excellence NIH/NIGMS P20GM103446NIGMS NIH HHS P20 GM103446NIH HHS NIH S10OD028725NIH HHS S10 OD028725State of Delaware (Delaware)
6 · The paper itself

Abstract

All biological products are required to demonstrate the absence of adventitious viruses (AVs), which may be inadvertently introduced at different steps involved in the manufacturing process. The currently recommended

Indexed as

Computational BiologyDatabases, GeneticHigh-Throughput Nucleotide SequencingVirusesAnimalsGenome, ViralHumansSARS-CoV-2high-throughput sequencingnext-generation sequencingreference virus database (RVDB)virus detection

Identifiers

PMID40548747
PMCPMC12306153

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.